Description

Lozartan Plus Teva Coated Tablets 100 mg/25 mg. №30

Ingredients:

Each tablet contains 100 mg of losartan potassium and 25 mg of hydrochlorothiazide.

Dosage:

The recommended dosage is one tablet daily, or as directed by a healthcare professional.

Indications:

Lozartan Plus Teva is indicated for the treatment of hypertension in patients whose blood pressure is not adequately controlled by losartan or hydrochlorothiazide alone.

Contraindications:

Do not use Lozartan Plus Teva if you are allergic to any of the ingredients, are pregnant, or have severe renal impairment.

Directions:

Swallow the tablet whole with a glass of water. It can be taken with or without food.

Scientific Evidence:

Studies have shown that the combination of losartan and hydrochlorothiazide in Lozartan Plus Teva provides a synergistic effect in lowering blood pressure. The dual action of losartan as an angiotensin II receptor blocker and hydrochlorothiazide as a diuretic helps in achieving better blood pressure control compared to monotherapy.

Additional Information:

It is important to monitor electrolyte levels and renal function regularly while taking Lozartan Plus Teva. This medication may cause dizziness or lightheadedness, especially during the first few days of treatment. Avoid driving or operating machinery until you know how this medication affects you.

Pharmacological Effects:

Losartan works by blocking the action of angiotensin II, a substance in the body that causes blood vessels to constrict. This relaxation of blood vessels helps lower blood pressure. Hydrochlorothiazide, on the other hand, increases urine output, reducing excess fluid in the body and further lowering blood pressure. The combination of these two medications in Lozartan Plus Teva provides a comprehensive approach to managing hypertension.

Clinical Trials and Comparative Effectiveness:

In a comparative study published in the Journal of Hypertension, the combination of losartan and hydrochlorothiazide was found to be more effective in reducing blood pressure compared to losartan alone. The study demonstrated that the dual therapy had a greater impact on both systolic and diastolic blood pressure levels, highlighting the enhanced efficacy of the combination.