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Treatment of all forms of parkinsonism, except for drug-induced parkinsonism. Treatment of idiopathic and symptomatic restless leg syndrome.
Description
Madopar composition
active substances: levodopa, benserazide;
1 tablet contains levodopa 200 mg and benserazide 50 mg in the form of benserazide hydrochloride 57 mg;
excipients: mannitol (E 421); calcium hydrogen phosphate anhydrous; microcrystalline cellulose; pregelatinized corn starch; crospovidone, type B; ethylcellulose; iron oxide red (E 172); colloidal anhydrous silica; sodium docusate; magnesium stearate.
Dosage form
Tablets.
Pharmacological properties
Dopamine, the lack of which in the basal ganglia is observed in patients with parkinsonism, is a neurotransmitter in the brain. Levodopa, or L-DOPA (3,4-dihydrophenylalanine), is an intermediate in dopamine synthesis. Levodopa replacement therapy as a drug is used to increase dopamine levels in the body due to its ability to penetrate well through the blood-brain barrier, unlike dopamine. Once levodopa enters the central nervous system (CNS), it is converted to dopamine by aromatic L-amino acid decarboxylase.
The dopaminergic system is involved in the pathogenesis of restless legs syndrome. Thus, levodopa replacement therapy is also effective for patients with restless legs syndrome.
Indications
It is used to treat Parkinson’s disease, parkinsonism. Refers to the group of dopaminergic drugs (i.e., reduces the production of prolactin by the body, i.e. eliminates hyperprolactinemia). In addition, Madopar replacement therapy is also effective in the treatment of patients with restless legs syndrome.
Patients with Parkinson’s disease have a lack of dopamine production. Levodop is an intermediate in the synthesis of dopamine. Therefore, replacement therapy with levodopa, one of the main active ingredients of Madopar, is used to increase the patient’s dopamine level. Levodopa has the ability to cross the blood-brain barrier, while dopamine does not. Madopar has an effective combination of active ingredients, therefore it has better efficacy and fewer side effects than levodopa, especially since levodopu is used in high dosages.
The combination of levodopa and benserazide hydrochloride is an effective compensation for dopamine deficiency in the brain.
Contraindications
Contraindicated intolerance to the active ingredients of Madopar, serious disorders of the liver and kidneys, decompensation of the CVS. It is not recommended for the treatment of patients who also suffer from bronchial asthma and stomach ulcers.
Children
The drug should not be used in children.
Application during pregnancy and lactation
Experiments carried out on animals have shown a negative effect on the fetus during gestation, therefore, taking the drug is prohibited during pregnancy. When taking the drug, women capable of reproduction should use reliable contraceptive methods.
Method of administration and dosage
Drug treatment begins with a small dose of Madopar-125, gradually increasing it (1 capsule per week) until optimal efficacy is found. The usual dose is 4 to 8 capsules per day, which is divided into several doses (3 to 4). The maximum dose is 10 capsules per day. When the dose is increased above the maximum for Madopar -125, the treatment is transferred to Madopar-250 (1 drop. 3 times a day). Madopar -62.5 is used for treatment with transient dosages.
When treating Madopar, it should be borne in mind that the simultaneous administration of Madopar with protein foods reduces its effectiveness.
Overdose
Symptoms of drug overdose are similar to the side effects listed in the corresponding section, but are characterized by their greater intensity and more pronounced. Gastric lavage should be performed, enterosorbents should be prescribed, symptomatic treatment should be prescribed.
Side effects
When treated with the drug, they can cause undesirable side effects of the nervous system, in particular, there is a high probability of developing anxiety, agitation, insomnia, confusion, hyperactivity. Gastric reactions are also possible – nausea, vomiting, diarrhea.
Violations from the CVS are possible, such as sinusoidal tachycardia, fluctuations in blood pressure, occasionally arrhythmia, hemolytic anemia, leukopenia, thrombocytopenia.
In rare cases, anorexia has been observed.
Storage conditions and periods
Can be stored for up to 4 years at a temperature not exceeding + 25 ° С.
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