$17.10
Magne-B6 is indicated for the prevention of complications associated with a lack of vitamin B6 and / or magnesium.
Description
Magne-B6 composition
active substances: 1 ampoule of 10 ml contains magnesium lactate dihydrate 186 mg and magnesium podolate 936 mg (corresponding to 100 mg Mg ++ or 4.12 mmol), pyridoxine hydrochloride (vitamin B6) 10 mg;
Excipients: sodium metabisulfite (E 223), sodium saccharin, caramel with the addition of cherries, purified water.
Dosage form
Solution for oral administration.
Pharmacological properties
Magnesium is an intracellular cation that reduces neuronal excitability and inhibits neuromuscular transmission, and is involved in many enzymatic reactions. Magnesium is an important component of body tissues: skeletal bones make up half of the total amount of magnesium contained in the body.
The concentration of magnesium in the serum from 12 to 17 mg / l (1-1.4 mEq / l, or 0.5-0.7 mmol / l) indicates magnesium deficiency; below 12 mg / l (1 mEq / l, or 0.5 mmol / l) – for severe magnesium deficiency.
Magnesium deficiency can be:
- primary, due to metabolic pathology (chronic congenital hypomagnesemia);
secondary, due to:
- insufficient intake of magnesium with food (irrational diet, chronic alcohol abuse, exclusively parenteral nutrition);
- impaired absorption of magnesium in the gastrointestinal tract (chronic diarrhea, fistulas of the gastrointestinal tract, hypoparathyroidism);
- excessive loss of magnesium due to renal excretion (tubular disorders, severe polyuria, diuretic abuse, chronic pyelonephritis, primary hyperaldosteronism, cisplatin treatment).
Indication
Treatment of confirmed magnesium deficiency in the body, both isolated and associated with other deficient conditions.
Contraindication
Hypersensitivity to any component of the drug. Severe renal insufficiency with a creatinine clearance of less than 30 ml / min. Phenylketonuria. Hypermagnesemia, vitamin B6 hypervitaminosis, myasthenia gravis. Atrioventricular block, severe hypotension. Concomitant use with levodopa. Diarrhea. Fructose intolerance, glucose or galactose malabsorption syndrome, sucrose-isomaltase deficiency (due to sucrose content).
Children
The drug Magne-B6 should be used in children weighing more than 10 kg (about 1 year old).
Use during pregnancy or breastfeeding
The use of magnesium during pregnancy is possible only if necessary after consulting a doctor.
Each of the active substances of the drug separately (both magnesium and vitamin B6) is not contraindicated in this period. Given the limited evidence for the use of the maximum recommended daily dose of vitamin B6 during breastfeeding, it is recommended to prescribe no more than 20 mg / day of vitamin B6.
Method of application and dosage
Dissolve the contents of the ampoules Magne-B6 in half a glass of water.
- Adults: 3-4 ampoules per day, with a total dose of 2 or 3 doses during meals.
- Children and infants weighing more than 10 kg (aged about 1 year): 10-30 mg / kg body weight per day (ie 0.4-1.2 mmol / kg body weight per day), which corresponds to 1-4 ampoules per day day, with the division of the total dose into 2 or 3 meals.
The drug should be discontinued as soon as blood magnesium levels return to normal.
Overdose
Magnesium overdose when administered orally does not usually lead to toxic reactions in patients with normal renal function. However, patients with renal insufficiency may develop magnesium intoxication.
Toxic effects depend on the levels of magnesium in the blood and are manifested by the following signs: a sharp drop in blood pressure, nausea, vomiting, central nervous system depression, reflex dysfunction, pathological changes in the ECG, the development of respiratory depression, coma, cardiac arrest and respiratory paralysis, anury.
Treatment: rehydration, forced diuresis. Patients with renal insufficiency require hemodialysis or peritoneal dialysis.
Side effects
Allergic reactions, diarrhea, nausea, vomiting, abdominal pain, skin reactions, including itching and urticaria.
Expiration date
3 years.
Storage conditions
Keep out of reach of children.
Store Magne-B6 in the original package at a temperature below 25 ° C.
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