Description

Meditan (Gabapentin) Capsules 300 mg. №30

Ingredients:

• Each capsule contains 300 mg of Gabapentin.

Dosage:

• The recommended dosage is as prescribed by a healthcare professional.
• Typically, the starting dose is 300 mg taken once on the first day, 300 mg twice a day on the second day, and 300 mg three times a day on the third day.

Indications:

• Meditan capsules are indicated for the management of seizures and neuropathic pain.
• It is also used in the treatment of restless legs syndrome and certain types of nerve pain.

Contraindications:

• Do not use Meditan if you are allergic to Gabapentin or any of the other ingredients in the capsules.
• It is important to consult a healthcare provider before starting this medication, especially if you have a history of kidney problems.

Directions:

• Swallow the capsules whole with a full glass of water. Do not crush or chew the capsules.
• It can be taken with or without food, but consistency is key to maintaining stable blood levels of the medication.

Scientific Evidence:

• Gabapentin, the active ingredient in Meditan, works by affecting certain chemicals in the body that are involved in the transmission of pain signals.
• Studies have shown its efficacy in managing neuropathic pain conditions such as diabetic neuropathy and postherpetic neuralgia.
• Research published in the *Journal of Pain Research* demonstrated that Gabapentin significantly reduced pain intensity and improved quality of life in patients with neuropathic pain.

Additional Information:

• It is important to follow the prescribed dosage and not to exceed it without medical advice.
• Abruptly stopping the medication can lead to withdrawal symptoms.
• If you experience any unusual side effects or reactions, contact your healthcare provider immediately.

Pharmacological Effects:

• Gabapentin exerts its pharmacological effects by binding to the α2δ subunit of voltage-gated calcium channels in the central nervous system.
• This action inhibits the release of excitatory neurotransmitters, thereby reducing neuronal hyperexcitability.
• By modulating calcium channel function, Gabapentin helps in controlling seizures and neuropathic pain.

Clinical Trials and Comparative Effectiveness:

• Clinical trials have demonstrated the efficacy of Gabapentin in various neuropathic pain conditions, showing comparable or superior effectiveness compared to other antiepileptic drugs.
• A study published in the *European Journal of Pain* compared the efficacy of Gabapentin with pregabalin in diabetic neuropathy and found similar pain reduction with both drugs, but with fewer side effects reported in the Gabapentin group.