Meratin Combi (ornidazole) vaginal tablets №10

Description

Meratin Combi composition
active substance: ornidazole, neomycin sulfate, nystatin, prednisolone;
1 tablet contains: ornidazole 500 mg, neomycin sulfate 100 mg, nystatin 100,000 IU, prednisolone 3 mg;
Excipients: corn starch, microcrystalline cellulose, propyl gallate, sodium methylparaben (E 219), sodium propylparaben (E 217), colloidal anhydrous silica, talc, magnesium stearate, sodium starch glycolate (type A), sodium.

Dosage form
Vaginal tablets.

Pharmacological properties
This drug Meratin Combi belongs to the group of antimicrobial and antiseptic substances, based on a complex of imidazole derivatives and corticosteroid components, which are used in the treatment of gynecological diseases.
The substances that make up the drug mutually complement the interaction, providing an increased effect during treatment.
In particular, ornidazole has the property of disrupting the structure of the DNA of microorganisms that are sensitive to its effects. The drug destroys the possibility of replication (reproduction) of cells of such pathological microorganisms for the human body as Trichomonas, amoeba, intestinal lamblia, as well as anaerobic bacteria – clostridia, fusobacteria and bacteroids, cocci.
Neomycin is an antibiotic from the amyglycoside group, highly active against bacteria of both gram-negative and gram-positive series.
Nystatin acts on fungal membranes, destroying the structure of the fungal cell and thus causing its death.
Prednisolone is a synthetic corticosteroid used to reduce inflammation. Has the ability to inhibit the secretion and release of inflammatory mediators. Its use also reduces the likelihood of scar tissue formation.

Indications
This drug Meratin Combi is used both in monotherapy and in combination, in particular, with the oral form, in the treatment and prevention of gynecological diseases and infections. In particular, when:

• bacterial vaginosis and vaginitis, trichomonas vaginitis, fungal vaginitis (candidiasis);
• vaginitis caused by mixed infections (Trichomonas, anaerobic flora, including gardnerella and yeast-like fungi);
• prevention of gynecological diseases before surgical treatment;
• for vaginal sanitation before childbirth or abortion;
• before and after the introduction of intrauterine contraceptives;
• before and after diathermocoagulation of cervical erosion;
• before intrauterine examination.

Contraindications
You should not use the specified drug if the patient has had a previous hypersensitivity (allergy) with respect to one of the components that are part of the drug – both basic and auxiliary.

Children
Meratin Combi is not used in children.

Application during pregnancy and lactation
Treatment of pregnant women is contraindicated in the first trimester.
In the II and III trimester, as well as during breastfeeding, treatment with this drug is allowed, since it enters the bloodstream in doses that are safe for the mother and child.

Method of administration and dosage
The Meratin Combi tablet is inserted in the supine position, before going to bed, deep into the vagina using an applicator, which is then withdrawn from the vagina. It is advisable to immerse the tablet in warm boiled water for 15-30 seconds before administration.
After the pill is injected, you must be in the “lying” position for at least one quarter of an hour.
This drug can be used with oral ornidazole.
The duration of treatment is 10 days. During menstruation, treatment is not stopped.

Overdose
Overdose with this drug has not been recorded at the moment.
If accidentally swallowed, it is advisable to induce vomiting, to take enterosorbents. In general, symptomatic treatment is recommended.

Side effects
The drug is usually well tolerated.
Some side effects may occur when you are treated with this drug.
In particular, the use of this drug can cause:

• allergic urticaria, skin rash;
• feeling of pain, itching, discomfort in the area of ​​drug administration;
• the occurrence of erosion;
• excessive intake of the drug into the blood can cause atrophy of the vaginal mucosa, inhibition of wound healing processes, cracks

Storage conditions and periods
This medicinal product is able to retain its medicinal properties for 2 years from the production date indicated on the package.
Storage is carried out in a dry place, away from sunlight.
Storage temperature should not exceed 25 ° C.