Mercazolil (thiamazolum) tablets 5 mg. №100

Description

Mercazolil composition
active substance: 1 tablet contains thiamazole 5 mg;
excipients: potato starch, calcium stearate, refined sugar, talc.

Dosage form
Tablets.

Pharmacological properties
Antithyroid agent. The mechanism of thyrostatic action is due to inhibition of the activity of the enzyme peroxidase, which is involved in the iodination of thyroid hormones, which leads to a violation of the synthesis of thyroxine and triiodothyronine. This property allows for symptomatic treatment of thyrotoxicosis, regardless of its etiology. Thiamazole does not affect the secretion of pre-synthesized thyroid hormones, which explains the duration of the latent period to normalize the concentration of thyroxine and triiodothyronine in the serum, which improves the clinical picture of the disease. Does not affect thyrotoxicosis, which developed due to the release of hormones after the destruction of thyroid cells (after treatment with radioactive iodine or thyroiditis).

Indications
Mercazolil is indicated for the treatment of diffuse toxical goiter, Graves’ disease, and Plummer’s disease. In addition, the drug is used in preparation for treatment with radioactive iodine, surgical interventions for thyrotoxicosis and prevention of thyrotoxicosis in the treatment of iodine-containing agents.

Contraindications
Mercazolil should not be used for the treatment of women during lactation and pregnancy. It is also recommended to refuse the appointment of the drug if the patient suffers from granulocytopenia, severe leukopenia and nodular forms of goiter.

Application during pregnancy and lactation
It is unacceptable to use the drug in the treatment of pregnant and lactating women. If it is necessary to treat a woman during lactation, the appointment of the drug is possible only if you refuse to feed.

Method of administration and dosage
Mercazolil tablets are for oral administration. The drug is recommended to be taken after meals. The tablets are swallowed whole, without chewing, and washed down with a small amount of liquid. When treating diseases of moderate severity, the patient should take 5 mg of the drug per day. In the treatment of severe forms of thyroid disease, the amount of the drug is doubled, in this case, the patient should use 10 mg of Mercazolil per day. After the required therapeutic effect is achieved, and the disease enters the remission stage, the dose of the drug must be reduced. Dosage reduction is carried out every 5 days by 5 or 10 mg. With a decrease in the dosage of the drug, the patient is first prescribed 5 mg per day, and then in the same dosage it is taken every two days, and later – once every three days.
Mercazolil treatment is carried out until a lasting therapeutic effect is achieved. The duration of treatment is selected individually. The maximum daily dose is 40 mg, single dose is 10 mg. The initial pediatric dosage should not exceed 0.4 mg per kg of body weight, the drug can be taken once or divided into two doses, the daily maintenance dose is 0.2 mg per kg of body weight.

Overdose
When taking the drug in increased doses, the patient may experience dry skin, changes in the menstrual cycle, myasthenic symptoms, drowsiness.
If symptoms of an overdose occur, the patient is advised to correct the received dose of the drug and prescribe symptomatic treatment.

Side effects
With long-term treatment with the drug, the patient may develop dizziness, alopecia, agranulocytosis, headaches, thrombocytopenia, pruritus, edema, arthralgia, nephropathic syndrome, liver damage, skin rash, visual impairment, nausea, cholestatic hepatitis, fever, aplastic anemia and drug-induced hypothyroidism.
If a patient develops at least one of the above side effects, it is necessary to consider discontinuing drug treatment or the need to adjust the dose.

Storage conditions and periods
The drug is stored in a dark, dry place out of the reach of children. The shelf life of the drug is 5 years.