Metoprolol (metoprolol tartrate) tablets 0.1g. №30

Description

Metoprolol composition
active substance: metoprolol;
1 tablet contains metoprolol tartrate 100 mg (0.1 g) in terms of dry 100% substance;
excipients: potato starch, lactose monohydrate, magnesium stearate, colloidal anhydrous silicon dioxide.

Dosage form
Tablets.

Pharmacological properties
It is a medicine used for heart disease. This agent is cardioselective, i.e. it blocks only beta-adrenergic receptors of the heart. Also suppresses the excessive stimulating effect of the sympathetic system. The drug reduces contractility, cardiac output, blood pressure.

Indications
Arterial hypertension; angina pectoris (including postinfarction); arrhythmias (including supraventricular tachycardia). Prevention of cardiac death and re-infarction after the acute phase of myocardial infarction. As part of complex therapy for thyrotoxicosis. Prevention of migraine attacks.

Contraindications
Metoprolol is not used:

• with allergies to the components of the tablets;
• at low pressure;
• with severe bronchial asthma;
• with bradycardia – heart rate less than 50 beats / minute;
• with pheochromocytoma;
• in case of impaired conduction of impulses in the heart (atrioventricular block II – III degree, sinoatrial blockade);
• with severe violations of arterial blood flow;
• with Prinzmetal’s angina;
• with acute heart failure;
• while taking some antidepressants, verapamil.

Children
The use of this drug is contraindicated in children.

Application during pregnancy and lactation
Prescribing to pregnant women is possible only on strict indications (there is a risk of developing bradycardia, hypotension, hypoglycemia in the fetus).
Breastfeeding mothers should stop breastfeeding.

Method of administration and dosage
The dose of Metoprolol is set individually. The maximum daily dose is 400 mg.
The tablets are taken orally, with a small amount of liquid, without chewing, after meals.
The duration of the course of treatment is set individually and can be 3 years.

• With arterial hypertension, the initial dose is 100 mg per day once or divided into two doses (morning and evening). If necessary, the daily dose can be increased to 200 mg.
• For angina pectoris, 50-100 mg of metoprolol tartrate is prescribed 2-3 times a day.
• For arrhythmias, appoint 50 mg 2-3 times a day. If necessary, the daily dose is increased to 300 mg, divided into 2-3 doses.
• With hyperthyroidism (thyrotoxicosis), 50 mg is prescribed 4 times a day. When a therapeutic effect is achieved, the dose is gradually reduced.
• With myocardial infarction (it is advisable to start treatment within the first 12 hours after the onset of chest pain): 50 mg every 6 hours for 48 hours, the maintenance recommended daily dose is 200 mg, divided into 2 doses. The course of treatment is at least 3 months.
• Prevention of migraine attacks: Metoprolol tartrate is prescribed at a dose of 100-200 mg per day, divided into 2 doses.

It is necessary to correct the dosage regimen in patients with impaired liver function.
Elderly patients and patients with renal insufficiency do not need dose adjustment.

Overdose
Overdose symptoms: pressure drop, slow heartbeat, nausea, dizziness, cyanosis of the skin, narrowing of the bronchi, fainting, vomiting, arrhythmia, in case of acute overdose – coma / loss of consciousness, shock, pain in the heart, the development of heart block, cardiac arrest. Symptoms of intoxication are more pronounced with the simultaneous administration of certain medications, alcohol.
Overdose treatment: discontinuation of intake, emergency gastric lavage (if impossible, stimulation of vomiting), intake of enterosorbents, monitoring of respiratory and circulatory parameters, kidney function, glucose levels, electrolytes in the blood. Perhaps the appointment of beta-adrenostimulants.

Side effects:

• Neurological disorders: sleep disorders, weakness, anxiety, muscle weakness, “nightmares”, slowing down of mental and motor reactions, tremors, dizziness, depression, memory impairments, convulsions, headache, confusion, anxiety, hallucinations.
• Cardiac disorders: drop in blood pressure, arrhythmia, heart pain, increased / slow heart rate, swelling of the legs, feet.
• Skin changes: redness, increased sweating, allergic reactions, rashes, baldness, exacerbation of psoriasis, sensitivity to the sun.
• Digestive Disorders: Stool disturbances, abdominal pain, taste changes, sclera / skin yellowness, dry mouth, dark urine, nausea.
• Respiratory disorders: bronchospasm, shortness of breath, nasal congestion.
• Perceptual disorders: discharge of tear fluid, decreased vision, sore eyes, dry eyes, conjunctivitis, tinnitus, hearing loss.
• A change in the blood test: a decrease in the number of platelets (manifested by unusual hemorrhages, bleeding, bruising), increased levels of sugar, liver enzymes, fats, bilirubin, thyroid hormones, and indicators of “white” blood.
• Others: weight gain, decreased potency, joint pain.

Storage conditions and periods
Store Metoprolol at 15–25 ° С for no more than 3 years.