Description

Metotab (Methotrexate) Tablets 10 mg. №30

Ingredients:

Each tablet contains 10 mg of Methotrexate.

Dosage:

The usual adult dosage is 7.5 to 20 mg once weekly. Dosage may vary based on the condition being treated. Consult a healthcare professional for the appropriate dosage.

Indications:

Metotab tablets are indicated for the treatment of certain types of cancer, severe psoriasis, and rheumatoid arthritis. It works by slowing or stopping the growth of cancer cells and suppressing the immune system.

Contraindications:

Do not take Metotab if you are pregnant, breastfeeding, or have liver disease. It is important to discuss your medical history with a healthcare provider before starting this medication.

Directions:

Take Metotab tablets orally as directed by your doctor. It is usually taken once a week. Follow all instructions on the product package.

Scientific Evidence:

Methotrexate has been extensively studied for its efficacy in treating various conditions. Research published in the Journal of Clinical Oncology has shown that Methotrexate is effective in the treatment of certain types of cancer, such as lymphoma and leukemia. Additionally, studies have demonstrated its effectiveness in managing autoimmune diseases like rheumatoid arthritis by reducing inflammation and joint damage.

Additional Information:

It is important to have regular blood tests while taking Metotab to monitor your body’s response to the medication. Inform your doctor of any side effects or concerns. Avoid prolonged sun exposure while on Methotrexate therapy.

Pharmacological Effects:

Methotrexate works by inhibiting dihydrofolate reductase, an enzyme involved in the synthesis of DNA, RNA, and proteins. This action leads to the suppression of cell proliferation, making it effective in treating cancer and autoimmune diseases. Methotrexate also modulates the immune response, reducing inflammation and tissue damage in conditions like rheumatoid arthritis.

Clinical Trials and Comparative Effectiveness:

Clinical trials have demonstrated the efficacy of Methotrexate in comparison to other disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis. A study published in Arthritis & Rheumatology found that Methotrexate was more effective in achieving disease remission and improving physical function compared to other DMARDs. Its long-term use has shown to slow disease progression and improve quality of life in patients with rheumatoid arthritis.