Description

Metotab (methotrexate) tablets 7.5 mg. №30

Ingredients

Active ingredient: Methotrexate 7.5 mg per tablet.

Dosage

Recommended dosage: The usual adult dose for rheumatoid arthritis and psoriasis is 7.5 mg once weekly. Dosage may vary based on the condition being treated. Consult your healthcare provider for the appropriate dosage.

Indications

Indicated for: Rheumatoid arthritis, psoriasis, and certain types of cancer. Methotrexate works by interfering with the growth of certain cells in the body.

Contraindications

Do not use if: Pregnant or breastfeeding, have liver disease, immunodeficiency, or a history of alcohol abuse. Consult your doctor before use.

Directions

Administration: Take Methotrexate tablets orally with a full glass of water. Follow your doctor’s instructions carefully. Do not crush or chew the tablets.

Scientific Evidence

Methotrexate is a well-studied medication with a strong scientific basis for its efficacy in treating various conditions. Research has shown that methotrexate is effective in managing rheumatoid arthritis by reducing inflammation and slowing down joint damage. Studies have also demonstrated its effectiveness in treating psoriasis by inhibiting the rapid growth of skin cells.

Additional Information

It is important to have regular blood tests while taking Methotrexate to monitor liver function and blood cell counts. Methotrexate may cause side effects such as nausea, fatigue, and liver abnormalities. Contact your healthcare provider if you experience any adverse reactions.

Pharmacological Effects: Methotrexate works by inhibiting dihydrofolate reductase, an enzyme involved in the synthesis of DNA, RNA, and proteins. This action leads to the suppression of cell proliferation, making it effective in treating conditions characterized by abnormal cell growth.

Clinical Trials: Clinical trials have shown Methotrexate to be a cornerstone therapy for rheumatoid arthritis and psoriasis. A study published in the New England Journal of Medicine found that Methotrexate was effective in reducing disease activity and joint damage in patients with rheumatoid arthritis.