Description

Metotrexat (Methotrexate) Tablets 10 mg. №50

Ingredients:

Each tablet contains 10 mg of Methotrexate.

Dosage:

The usual adult dosage for Methotrexate tablets is 7.5 to 20 mg once weekly. Dosage may vary based on the condition being treated. Consult your healthcare provider for the appropriate dosage.

Indications:

Methotrexate tablets are indicated for the treatment of certain types of cancer, severe psoriasis, and rheumatoid arthritis. It works by slowing or stopping the growth of cancer cells and suppressing the immune system in autoimmune conditions.

Contraindications:

Do not take Methotrexate if you are pregnant, breastfeeding, or have liver disease. It is important to discuss all your medical conditions and medications with your doctor before starting Methotrexate.

Directions:

Take Methotrexate tablets exactly as prescribed by your healthcare provider. Swallow the tablet whole with a full glass of water. Do not crush or chew the tablet.

Scientific Evidence:

Methotrexate has been extensively studied for its efficacy in treating various conditions. Research published in the Journal of Clinical Oncology has shown that Methotrexate is effective in the treatment of certain types of cancer, including leukemia and lymphoma. Additionally, studies in the Annals of the Rheumatic Diseases have demonstrated the effectiveness of Methotrexate in managing rheumatoid arthritis.

Additional Information:

It is important to have regular blood tests while taking Methotrexate to monitor liver function and blood cell counts. Methotrexate may cause side effects such as nausea, vomiting, and hair loss. If you experience any severe side effects, contact your healthcare provider immediately.

Pharmacological Effects: Methotrexate works by inhibiting dihydrofolate reductase, an enzyme involved in the synthesis of DNA, RNA, and proteins. This action leads to the suppression of cell proliferation, making it effective in treating cancer and autoimmune diseases.

Clinical Trials: Clinical trials have shown Methotrexate to be a cornerstone therapy in the management of rheumatoid arthritis, with significant improvements in disease activity and joint damage progression. Studies have also highlighted its role in reducing the risk of relapse in certain types of cancer.