Description

Metotrexat (Methotrexate) Tablets 10 mg. №50

Ingredients:

• Each tablet contains 10 mg of Methotrexate.

Dosage:

• The usual adult dosage for Methotrexate tablets is 7.5 to 20 mg once weekly.
• Dosage may vary based on the condition being treated.

Indications:

• Methotrexate tablets are indicated for the treatment of certain types of cancer, severe psoriasis, and rheumatoid arthritis.
• It works by slowing or stopping the growth of cancer cells and suppressing the immune system in autoimmune conditions.

Contraindications:

• Do not take Methotrexate if you are pregnant, breastfeeding, or have liver disease.
• It is important to discuss all your medical conditions and medications with your doctor before starting Methotrexate.

Directions:

• Take Methotrexate tablets exactly as prescribed by your healthcare provider.
• Swallow the tablet whole with a full glass of water. Do not crush or chew the tablet.

Scientific Evidence:

• Methotrexate has been extensively studied for its efficacy in treating various conditions.
• Research published in the Journal of Clinical Oncology has shown that Methotrexate is effective in the treatment of certain types of cancer, including leukemia and lymphoma.
• Studies in the Annals of the Rheumatic Diseases have demonstrated the effectiveness of Methotrexate in managing rheumatoid arthritis.

Additional Information:

• It is important to have regular blood tests while taking Methotrexate to monitor liver function and blood cell counts.
• Methotrexate may cause side effects such as nausea, vomiting, and hair loss.
• If you experience any severe side effects, contact your healthcare provider immediately.

Pharmacological Effects:

• Methotrexate works by inhibiting dihydrofolate reductase, an enzyme involved in the synthesis of DNA, RNA, and proteins.
• This action leads to the suppression of cell proliferation, making it effective in treating cancer and autoimmune diseases.

Clinical Trials:

• Clinical trials have shown Methotrexate to be a cornerstone therapy in the management of rheumatoid arthritis, with significant improvements in disease activity and joint damage progression.
• Studies have also highlighted its role in reducing the risk of relapse in certain types of cancer.