Metrogyl (metronidazole) vaginal gel 30 g. with aplicator

Description

Metrogyl composition
active substance: metronidazole;
1 g of gel contains metronidazole – 10 mg;
excipients: propyl parahydroxybenzoate (E 216), propylene glycol, carbomer 940, disodium edetate, sodium hydroxide, purified water.

Dosage form
Vaginal gel.

Pharmacological properties
It is an antimicrobial agent used in gynecology. The effectiveness is ensured by the presence of metronidazole in this drug, which is 5-nitroimidazole. The mechanism of its action is due to the ability to interact with deoxyribonucleic acid (DNA) of cells of microorganisms. In this case, the production of nucleic acids is inhibited and bacteria die. Active against protozoa: Entamoeba histolytica, Trichomonas vagіnalis, Giardia lamblia, as well as facultative anaerobes Bacteroides spp. (Bacteroides ovatus, Bacteroides fragilis, Bacteroides distasonis, Bacteroides thetaiotaomіcron, Bacteroides vulgaris), Prevotella spp. (Prevotella buccae, Prevotella bivia, Prevotella disiens), Fusobacterium spp., Veіllonella spp., Some facultative obligate (Clostrіdium spp.), Facultative (Eubacterіum spp., Peptococcus spp., Peptostrobate. Gardnerella vaginalis. Aerobes are insensitive to metronidazole, but in the presence of mixed flora (anaerobes + aerobes), it acts synergistically with antibiotics.

Indications
Metrogyl Vaginal is prescribed for the local treatment of bacterial vaginosis, nonspecific vaginitis, incl. Trichomonas.

Contraindications:

• if you are allergic to metronidazole, nitroimidazole derivatives;
• with intolerance to auxiliary components.

It is used with caution in blood diseases, leukopenia, in diseases of the central nervous system (for example, epilepsy), in liver failure.

Children
The safety and effectiveness of the drug in children have not been studied.

Application during pregnancy and lactation
This medication is contraindicated during pregnancy.
The active ingredient is able to penetrate into breast milk, therefore, breastfeeding during the treatment period should be canceled. You can resume feeding no earlier than 48 hours after the end of the use of this medication.

Method of administration and dosage
Metrogyl Vaginal is used intravaginally (inserted into the vagina). The applicator is filled with gel and gently inserted into the vagina, slowly pressing the plunger, squeezing out the gel.
The recommended dose is 5 g (1 applicator) 2 times / day (morning and evening).
The course of treatment is 5 days. During the treatment period, sexual intercourse should be avoided.

Overdose
Symptoms of an overdose with Metrogyl Vaginal: leukopenia, vomiting, abdominal pain, neuropathy, diarrhea, impaired coordination, paresthesia, metallic taste in the mouth, dizziness, convulsions.
Treatment: discontinuation, maintenance therapy.

Side effects

• Digestive upsets: dry mouth, nausea, change in taste, metallic taste, abdominal cramping, loss of appetite, constipation or diarrhea.
• Local reactions: irritation, pain in the vagina, itching, burning, thick mucous membranes, white vaginal discharge, frequent urination, vaginal candidiasis, irritation of the penis and sexual partner.
• Neurological disorders: headache, dizziness.
• Hematopoiesis changes: leukopenia, leukocytosis.
• Allergic reactions: itching of the skin, urticaria, rash.

There may be a reddish-brown staining of urine.

Storage conditions and periods
At 15-25 ° С, no more than 3 years.