Description

Metronidazol (Metronidazole) Solution for Infusions 0.5% 100 ml

Ingredients

Active ingredient: Metronidazole. Inactive ingredients may include sodium chloride, citric acid, and water for injection.

Dosage

Dosage: The usual dose is 500 mg infused over 1 hour every 8 hours. Dosage may vary based on the condition being treated.

Indications

Indications: Metronidazole is indicated for the treatment of various infections caused by susceptible anaerobic bacteria and parasites.

Contraindications

Contraindications: Do not use in patients with a history of hypersensitivity to metronidazole or other nitroimidazole derivatives.

Directions

Administration: Administer by intravenous infusion only. Follow the instructions provided by your healthcare provider.

Scientific Evidence

Metronidazole exerts its antimicrobial effects by disrupting DNA and protein synthesis in susceptible organisms. Studies have shown its efficacy in treating infections such as bacterial vaginosis, trichomoniasis, and certain anaerobic bacterial infections.

Additional Information

Metronidazole has been extensively studied and is considered a first-line treatment for many anaerobic infections. Clinical trials have demonstrated its effectiveness in various clinical settings, including gynecological and gastrointestinal infections.

Pharmacological Effects: Metronidazole enters bacterial and protozoal cells where it is reduced by microbial enzymes to an active form. This leads to DNA damage and cell death, effectively treating the infection.

Comparative Effectiveness: Metronidazole is comparable in efficacy to other antibiotics like clindamycin and tinidazole in treating anaerobic infections. However, its broad spectrum of activity and low cost make it a preferred choice in many clinical scenarios.