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Micardis is an antihypertensive drug (lowering blood pressure). The active substance of this drug blocks the receptors of angiotensin II (a protein that increases blood pressure) and eliminates its vasoconstrictor effect. Micardis reduces systemic blood pressure, reduces the concentration of the hormone aldosterone in the blood.
The drug is indicated for arterial hypertension.
Description
Micardis composition
active substance: telmisartan;
1 tablet contains telmisartan 80 mg;
Excipients: sodium hydroxide, povidone (E 1201), meglumine, sorbitol (E 420), magnesium stearate (E 470b).
Dosage form
Tablets.
Pharmacological properties Micardis belongs to the group of antihypertensive drugs.
It is an angiotensin II receptor, to a combination that includes telmisartan as an antagonist and hydrochlorothiazide as a thiazide diuretic (diuretic drug).
When taken together, the antihypertensive effect of these drugs is more pronounced, blood pressure decreases more actively than if they are used separately. With a single daily intake for a long time, blood pressure is stable, although gradually, decreases.
Telmisartan has the property of causing a decrease in the concentration of the steroid hormone aldosterone in the blood, while it does not inhibit the proteolytic enzyme renin in the blood plasma, does not cause blocking of ion channels.
Also, telmisartan does not affect the inhibition of the angiotensin-converting enzyme kininase-II. The latter does not cause the destruction of bradykinins and, along with them, the appearance of side effects usually caused by bradykinin.
After taking the drug, it causes a noticeable effect after 3 hours, then it produces an effect for another 24 hours, and within 48 – the effect is still significant for the human body. A persistent decrease in blood pressure develops after 4 weeks of continuous administration of the drug.
In this case, the heart rate does not depend on the influence of telmisartan.
If the drug is abruptly canceled, “withdrawal syndrome” will not occur.
Studies have shown that regular use of this drug leads to a proven decrease in the number of cardiovascular diseases in patients with blood vessel diseases, diabetes mellitus, and other systemic diseases that can accompany and potentiate arterial hypertension.
Indications
Micardis is an antihypertensive drug (lowering blood pressure). The active substance of this drug blocks the receptors of angiotensin II (a protein that increases blood pressure) and eliminates its vasoconstrictor effect. Micardis reduces systemic blood pressure, reduces the concentration of the hormone aldosterone in the blood.
The drug is indicated for arterial hypertension.
Contraindications
This drug is contraindicated in case of hypersensitivity to it, severe renal / hepatic failure, biliary obstruction, hereditary fructose intolerance.
Also, the drug is not used in adolescence and childhood, pregnant women, women who are breastfeeding.
Application during pregnancy and lactation
The use of the antihypertensive drug is contraindicated during pregnancy.
A woman needs to stop breastfeeding while on therapy with this drug.
Method of administration and dosage
The drug is received regardless of food intake, inside.
Adult patients are advised to receive Mikardis 40 mg once a day. For some patients, the use of this drug at a dose of 20 mg / day is sufficient to obtain the optimal therapeutic effect.
If necessary (insufficient lowering of high blood pressure), it is allowed to increase the dose of this drug to 80 mg 1 time per day.
In severe arterial hypertension, the dose of Mikardis can be up to 160 mg / day.
The maximum effectiveness of the antihypertensive effect of Mikardis is usually noted four to eight weeks after the start of therapy.
Overdose
An overdose of Micardis is characterized by a pronounced decrease in blood pressure.
In case of an overdose, the patient undergoes symptomatic therapy. Hemodialysis is ineffective in this case.
Side effects
When using the drug , the following side effects may develop in the patient: a pronounced decrease in blood pressure, dizziness, fatigue, headache, insomnia, depression, anxiety, convulsions, chest pain, bradycardia / tachycardia, upper respiratory tract infections (including pharyngitis, bronchitis ), sinusitis, cough, nausea, diarrhea, abdominal pain, dyspeptic symptoms, increased activity of liver enzymes, myalgia (muscle pain), arthralgia (joint pain), peripheral edema, back pain, urinary tract infections, flu-like syndrome, erythema, dyspnea (respiratory failure), syncope.
Storage conditions and periods
The drug Micardis should be stored in a dry place; storage temperature – below + 30 ° C.
Store the drug out of the reach of children.
The shelf life of this medicine is four years.
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