Midostad Combi solution for injections 1ml. №5

$15.00

Midostad Combi is used when necessary to relieve muscle cramps (spasticity). Including for the relief of post-stroke spasticity in cases where the injection form is the method of choice.

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Description

Midostad Combi composition
Main active ingredients: lidocaine hydrochloride, tolperisone hydrochloride.
Auxiliary components: methyl parahydroxybenzoate, diethylene glycol monoethyl ether, water for injection.
1 ml of the drug contains 100 mg of tolperisone hydrochloride and 2.5 mg of lidocaine hydrochloride.

Release form
It is produced in the form of an injection solution packed in 1 ml ampoules.

Pharmacological properties
Midostad Combi belongs to the group of muscle relaxants with a central action.
The effect of the application is due to the properties of the main active ingredients – lidocaine, tolperisone hydrochloride.
The drug produces membrane stabilizing and local anesthetic effects, some spinal reflexes.
It also has a secondary mechanism of action due to the ability to block the release of the transmitter due to the blockade of calcium ions entering the synapses.
Able to enhance peripheral blood circulation, reduce muscle tone increase, as well as muscle stiffness, acting as an antispasmodic.
Lidocaine has such a mechanism of action, due to which it has the ability to block sodium channels. Such properties make it possible to stabilize the neuronal membrane, helping to reduce its permeability, and arresting the ability to conduct impulses. As a result, it has a quick analgesic effect.
Due to the fact that the drug contains several active components, they complement each other, produce an increased effect from its use.

Indications
Midostad Combi is used when necessary to relieve muscle cramps (spasticity). Including for the relief of post-stroke spasticity in cases where the injection form is the method of choice.

Contraindications
Not applicable if the patient has hypersensitivity (allergy) to one of the components that make up the drug.
Not applicable for myasthenia gravis.

Children
It is intended only for use in patients over 18 years of age.

Application during pregnancy and lactation
Treatment of pregnant women with this drug is contraindicated only in the first trimester. In the future, the need for an appointment is determined by the attending physician, based on the benefit / harm ratio.
During treatment, lactation should be suspended.

Method of administration and dosage
For parenteral administration only.
Midostad Combi is administered intramuscularly:

  • 1 time a day, 100 mg as a slow injection;
  • 2 times a day, 100 mg.

The duration of treatment is determined by the attending physician, depending on the nature of the course of the disease and the effectiveness of treatment, the patient’s individual response to the drug.

Overdose
Overdose symptoms were observed in cases where the daily dose of the drug (in children) exceeded 300-600 mg per day.
In the course of studies, it was noted that acute intoxication with the introduction of high dosages caused symptoms such as:

  • ataxia;
  • tonic-clonic seizures;
  • difficulty breathing, even to the point of stopping it.

There is no specific antidote for tolperisone.
In case of an overdose, it is recommended to cancel the administration of the drug, symptomatic and supportive treatment is prescribed.

Side effects
The following side effects may occur, such as:

  • anemia, lymphadenopathy;
  • anaphylactic shock, convulsions, tremors;
  • anorexia, polydipsia;
  • insomnia, depression, headache;
  • tremor, convulsions, hyperesthesia, paresthesia;
  • tinnitus, vertigo;
  • angina pectoris, tachycardia, lowering blood pressure, bradycardia;
  • hypotension, skin hyperemia;
  • difficulty breathing, nosebleeds, shortness of breath;
  • diarrhea, dryness of the oral mucosa, dyspepsia, nausea, epigastric pain, constipation, flatulence, vomiting.

If you have any unusual side effects as a result of taking this drug, you should consult your doctor about possible changes in the treatment regimen.

Storage conditions and periods
The shelf life of the drug is no more than 2 years.
This medicinal product should be stored in a dry place out of the reach of children, at a temperature not lower than 8, not higher than 15 ° C.