Mononitrosid (isosorbide Mononitrate) tablets 0.04 g. №40

Description

Mononitrosid composition
active substance: isosorbide mononitrate;
1 tablet contains diluted isosorbide mononitrate, equivalent to isosorbide mononitrate 40 mg;
Excipients: lactose monohydrate, microcrystalline cellulose, corn starch, talc, magnesium stearate.

Dosage form
Tablets.

Indications
Mononitrosid is used in the combined treatment of chronic heart failure, pulmonary hypertension, pulmonary heart disease. In addition, Mononitrosid is used to prevent the onset of angina attacks in patients who suffer from coronary heart disease.

Contraindications
Mononitrosid is not prescribed for patients with cardiac tamponade, left ventricular failure with low diagnostic pressure, arterial hypovelemia, arterial hypotension. The drug is contraindicated in patients with angle-closure glaucoma, shock, vascular collapse, toxic pulmonary edema, hypersensitivity to the drug components, myocardial infarction in the acute period, accompanied by severe arterial hypotension. It is not prescribed for pregnant women, patients under 18 years of age and women in the lactation stage.
Relative contraindications to the appointment of Monosan are mitral and aortic stenosis, hypertrophic cardiomyopathy, renal failure, liver dysfunction, thyrotoxicosis, old age, severe arrhythmias and a tendency to orthostatic disorders of vascular regulation.
During therapy, it is necessary to constantly monitor blood pressure as well as heart rate.

Children
The drug should not be used in children.

Application during pregnancy and lactation
In order to prevent the occurrence of an undesirable effect of Mononitrosid on the development of the fetus and newborn, in the treatment of nursing and pregnant women, the use of the drug is possible only in extreme cases and after the balance of harm and benefit.

Method of administration and dosage
The drug should be used orally before meals, without chewing and drinking plenty of fluids.
The dose and frequency of administration is set by the doctor individually. In order to achieve the maximum therapeutic effect, individual dosage of the drug is recommended depending on the patient’s condition, his reaction to the drug and tolerability.
Start treatment with low doses, which in the process of treatment, if necessary, increase. The recommended dose is 40 mg 2 times a day. In most cases, prescribe 20 mg 2 times a day or 40 mg 2 times a day in the morning and afternoon.
In order to prevent the development of tolerance to nitrates (at any dosage regimen), it is recommended to take the second tablet no earlier than 8 hours after taking the first.
In the treatment of angina pectoris with frequent nocturnal attacks, the drug should be used in the morning and just before bedtime.
Hemodynamic monitoring is important to determine individual dosage.
The daily dose, depending on the severity of the disease, can reach 120 mg (maximum daily dose), divided into 3 doses.

Overdose
Taking high doses of Mononitrosid can cause collapse, fainting, reflex tachycardia, dizziness, weakness, visual disturbances, lethargy, skin hyperemia, headaches, nausea, diarrhea, vomiting, sweating, seizures, coma, paralysis, hyperthermia.
To eliminate poisoning, the patient needs to perform gastric lavage, to ensure constant monitoring of the work of vital organs. With a pronounced decrease in pressure, the patient is taken measures, the direction to increase the volume of circulating blood, and in severe cases, the introduction of norepinephrine or dopamine is indicated.

Side effects
In the treatment of Mononitrosid , some patients may experience allergic reactions, visual impairment, drowsiness, stiffness, cerebral ischemia, a decrease in the speed of psychomotor reactions, transient hyperemia of the facial skin, dizziness, “nitrate” headaches, a decrease in blood pressure, tachycardia, orthostatic collapse and paradoxical increase attacks of angina pectoris.

Storage conditions and periods
Mononitrosid should be stored in a dry, protected from light and moisture, at a temperature not exceeding 25 ° C. Duration of storage of the drug Monosan – 4 years.