Moxifloxacin Sandoz coated tablets 400 mg. №7

Description

Moxifloxacin composition
The main active ingredient: moxifloxacin.
Excipients: microcrystalline cellulose, corn starch, anhydrous colloidal silicon dioxide, magnesium stearate, sodium starch glycolate, talc, etc.

Release form
The drug is produced in the form of tablets, each containing 400 mg of moxifloxacin.

Pharmacological properties
Moxifloxacin belongs to a group of antibacterial drugs that are used systemically in the treatment of various infectious and inflammatory diseases.
Moxifloxacin, which is the main active ingredient of the drug, is the newest antibiotic and belongs to the group of fourth generation fluoroquinolones.
Moxifloxacin has all the positive qualities of the first three generations of fluoroquinolones.
At the same time, the spectrum of its bactericidal effect includes a wide range of both gram-negative and gram-positive, anaerobic and acid-resistant microorganisms pathogenic for humans – clostridia, mycoplasma, chlamydia, legionella, staphylococci, streptococci, enterococci, gardnerella, hemacophilus infections, enterobacteria dr.
The specified substance is well tolerated, therefore it has almost no contraindications. Its use causes a very small number of side effects (comparable to other antibiotics) and even long-term use rarely causes the development of antibiotic resistance, including if the patient has previously taken antibiotics of the tetracyclines, cephalosporins, penicillins, aminlycosides or macrolides group.

Indications
Moxifloxacin is indicated for the treatment of systemic infections caused by microflora sensitive to moxifloxacin, including those that have already shown multiple antibiotic resistance.
In particular, for treatment:

• community-acquired pneumonia, bacterial sinusitis, other infections of the respiratory system;
• complicated infectious lesions of the skin and subcutaneous tissues (including an infected diabetic foot);
• complicated intra-abdominal infections, including polymicrobial;
• infections of the pelvic organs, including abscesses.

Contraindications
The drug in question is not used if the patient has ever had hypersensitivity (allergy) to one of the components that make up its composition.
Do not use if there is a risk of tendon rupture, or if the patient suffers from:

• bradycardia;
• arrhythmia;
• electrolyte imbalance.

Children
Also contraindicated for the treatment of children and adolescents, up to 18 years of age.

Application during pregnancy and lactation
This drug is contraindicated for the treatment of pregnant women.
Lactation is suspended for the duration of treatment with this drug.

Method of administration and dosage
The exact duration of the therapeutic course is determined by the attending physician, depending on the type and strength of the infection.
The recommended dosage regimen for moxifloxacin is 400 mg once a day, regardless of the type of infection. It is not recommended to exceed the recommended dosage.
At the beginning of treatment, the drug is used in the form of an intravenous infusion, administered by drip. After noticeable improvements in the patient’s condition, the patient is transferred to the oral form of moxifloxacin (tablets), with the same dosage – 400 mg of the drug per day (1 tablet).
Duration of the therapeutic course:

• community-acquired pneumonia – 10 days, bronchitis – 5-10 days;
• complicated infections of the skin and subcutaneous tissues – 1-3 weeks;
• complicated intra-abdominal infections – from 5 days to 2 weeks.

Duration of administration is given for all forms of moxifloxacin.
It is not recommended to exceed the recommended duration of treatment.
Elderly patients, patients with renal or hepatic insufficiency do not need dosage adjustment.

Overdose
Overdoses with this drug are extremely rare.
Increased side effects are possible.
In case of accidental overdose, the electrocardiogram should be monitored and symptomatic treatment applied.
If an overdose occurred while taking the oral form of the drug, the intake of enterosorbents can improve the patient’s condition.

Side effects
The use of this drug in a patient can cause side effects in the form of:

• candidal superinfection, anemia, leukopenia, neutropenia, thrombocytopenia, thrombocythemia;
• changes in thromboplastin levels;
• allergic reactions, itching, rash, allergic urticaria, eosinophilia, anaphylactic shock, angioedema;
• hyperlipidemia, hyperglycemia, hyperuricemia;
• anxiety, excitement, mood swings, hallucinations, depression;
• paresthesia, dysesthesia, hypoesthesia, hyperesthesia;
• ageusia;
• headache, dizziness, confusion, insomnia, tremors, vertigo;
• nightmares, walking disorders, impaired coordination of movements, seizures;
• attention disorders, speech disorders, amnesia;
• visual and hearing impairment;
• prolongation of the Q – T interval in patients with hypokalemia;
• tachycardia, arrhythmias, cardiac arrest;
• vasodilation, loss of consciousness, arterial hypotension;
• shortness of breath, edema;
• nausea, vomiting, abdominal pain, anorexia, constipation, diarrhea, dyspepsia, flatulence, gastroenteritis, jaundice, hepatitis;
• tendinitis, tendon rupture, arthralgia, myalgia;
• dehydration, hyperhidrosis;
• phlebitis at the injection site.

Storage conditions and periods
This medicinal product retains its medicinal properties for 3 years, which are counted from the production date specified by the manufacturer.
The drug should be kept out of the reach of children. No other special storage conditions are required.