$47.00
It is prescribed for arterial hypertension.
Description
Moxogamma composition
active substance: moxonidinum;
1 tablet contains moxonidine 0.3 mg;
Excipients: lactose monohydrate, crospovidone, povidone K 25, magnesium stearate, Opadry B-1-7000 (contains hydroxypropylmethylcellulose, titanium dioxide (E 171), macrogol 400), iron oxide red (E 172).
Dosage form
Film-coated tablets.
Pharmacological properties
It is a selective agonist of imidazoline receptors in the brain stem. These receptors are found mainly in the rostral region of the ventrolateral region of the medulla oblongata, which plays an important role in the control of the sympathetic branch of the nervous system. As a result of the interaction of the drug with imidazoline receptors, the activity of the sympathetic nervous system changes, which leads to a decrease in blood pressure.
Indications
It is prescribed for arterial hypertension.
Contraindications
You can not use Moxogamma :
- with hypersensitivity to any component of the drug;
- with sick sinus syndrome, sinoatrial heart block;
- with bradycardia (heart rate less than 50 beats / minute at rest);
- with AV blockade of II – III degree;
- with heart failure.
Children
Efficacy and safety of the drug in children have not been established, so the drug should not be prescribed to this age group.
Application during pregnancy and lactation
There are no data on the use of moxonidine during pregnancy. Animal studies demonstrate fetal toxicity. The risk to humans is unknown. This medicine should not be used in pregnant women unless absolutely necessary.
Moxonidine can be excreted in breast milk, so it should not be used when breastfeeding.
Method of administration and dosage
The tablet is taken with or without food. For adults, treatment begins with the lowest dose – 0.2 mg. If the effect is insufficient, after 3 weeks the dose is increased to 0.4 mg. The required dose is taken 1 time (in the morning) or divided into 2 doses (morning and evening). If the effect is insufficient, the dose can be increased after 3 weeks (up to a maximum of 0.6 mg). Do not exceed a single dose – 0.4 mg, daily – 0.6 mg.
Reception should be stopped gradually – over 2 weeks, reduce the dose.
Overdose
Overdose symptoms: sedation, headache, drowsiness, dizziness, arterial hypotension, general weakness, vomiting, bradycardia, dry mouth, pain in the upper abdomen, malaise. In case of severe overdose, careful monitoring of respiration (possibly depression of the respiratory center), consciousness is necessary. No specific antidotes are known. In the case of arterial hypotension, it is recommended to use dopamine to support blood circulation and the introduction of plasma replacement solutions. Atropine is used when bradycardia appears.
Side effects:
- The most common: dry mouth, dizziness, drowsiness, general weakness, asthenia.
- Disturbances from the organ of vision: ringing in the ears.
- Disorders from the nervous system: dizziness, drowsiness, headache, fainting.
- Disorders from the digestive tract: nausea, dyspepsia, dry mouth, diarrhea.
- Disorders of the skin / subcutaneous tissue: allergy reactions, including itching, rash, angioedema.
- Mental disorders: nervousness, insomnia.
- Disorders from the cardiovascular system: arterial hypotension (including orthostatic), bradycardia.
- Disorders from the musculoskeletal system, connective tissue: neck pain, back pain.
- General disorders: edema, asthenia.
Expiration date
3 years for dosages of 0.3 mg.
Storage conditions
Store Moxogamma in the original package at a temperature not exceeding 30 ° C out of reach of children.
Recent Reviews