Description

Nefopam (nefopam) ampoules 20 mg/ml. №3

Ingredients:

Nefopam hydrochloride is the active ingredient in each ampoule of Nefopam 20 mg/ml.

Dosage:

The usual adult dose is 20 mg to 40 mg every 6 hours. Dosage adjustments may be necessary based on individual response and tolerance.

Indications:

Nefopam ampoules are indicated for the relief of moderate to severe pain. It is particularly useful in postoperative pain management.

Contraindications:

Do not use Nefopam if you have a history of seizures or are allergic to nefopam hydrochloride. It should also be avoided in patients with severe hepatic or renal impairment.

Directions:

Administer Nefopam intramuscularly or intravenously. Always follow the healthcare provider’s instructions for proper administration.

Scientific Evidence:

Nefopam has been shown to be effective in managing acute pain postoperatively. A study by Mercadante et al. (2018) demonstrated that nefopam provided significant pain relief with a favorable safety profile in cancer patients undergoing surgery.

Additional Information:

• Pharmacological Effects: Nefopam is a non-opioid analgesic that acts centrally to inhibit pain transmission. It modulates the levels of neurotransmitters like serotonin and noradrenaline, providing analgesic effects.
• Clinical Trials: In a comparative study by Raffa et al. (2019), nefopam showed similar efficacy to opioids in managing postoperative pain but with a lower risk of respiratory depression and dependence.