Nefrotect solution for infusions 250 ml. №10 vial

$434.00

Nephrotect is used for parenteral nutrition for patients suffering from diseases accompanied by impaired renal function (acute renal failure, chronic renal failure), including individuals on hemodialysis (including during a dialysis session).

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Description

Nefrotect composition
Composition (per 1000 ml):

  • Glycine – 5310 mg;
  • L-Phenylalanine 3500 mg
  • L-lysine monoacetate – 1690 mg;
  • L-Leucine – 1280 mg;
  • L-serine – 7600 mg;
  • L-Isoleucine 5800 mg
  • L-methionine – 2000 mg;
  • L-arginine – 8200 mg;
  • N-acetyl-L-cysteine ​​- 540 mg;
  • L-valine – 8700 mg;
  • L-threonine – 8200 mg;
  • L-histidine – 9800 mg;
  • L-Alanine – 6200 mg;
  • L-proline – 3000 mg;
  • L-Tyrosine 600 mg

Release form
Available as a solution for infusion.

Pharmacological properties
This product is intended for parenteral (intravenous) nutrition of patients with various pathologies, which is accompanied by insufficient renal function (in cases where enteral nutrition is ineffective or impossible).
The amino acids that make up this medicine are physiological components. When administered parenterally, they are quickly included in the pool of free amino acids, are involved in all metabolic processes of the body, in particular in the biosynthesis of proteins.

Indications
Nefrotect is used for parenteral nutrition for patients suffering from diseases accompanied by impaired renal function (acute renal failure, chronic renal failure), including individuals on hemodialysis (including during a dialysis session).

Contraindications:

  • with phenylketonuria;
  • in violation of amino acid metabolism;
  • with overhydration;
  • with allergies to components;
  • in case of shock;
  • with hypoxia;
  • with pulmonary edema;
  • with decompensated heart failure;
  • with renal failure (if it is impossible to carry out hemodialysis / hemofiltration);
  • with metabolic acidosis;
  • with severe liver failure.

Application during pregnancy and lactation
Only on the recommendation of a doctor.

Method of administration and dosage
Nefrotect is intended for long-term intravenous drip (preferably in the central veins). The Nefrotect solution can be mixed with other solutions (under aseptic conditions) or administered through a separate infusion system.
When used during a hemodialysis session, Nefrotect can be directly injected into the injection port of the hemodialysis device (no fat or glucose).
Dosage is selected individually.
Patients with acute renal failure / chronic renal failure are administered:

  • for patients on hemodialysis: 0.8-1.2 g / kg / day (8-12 ml / kg / day);
  • patients without dialysis: 0.6–0.8 g / kg / day (6–8 ml / kg / day);
  • to replenish the loss of amino acids in individuals undergoing hemodialysis for a long time: 0.5–0.8 g / kg per dialysis procedure (5–8 ml / kg per hemodialysis procedure).

The maximum dose is 0.8–1.2 g / kg / day (8–12 ml / kg / day or 560–840 ml / day for 70 kg patients).
Maximum solution injection rate:

  • for parenteral nutrition – 0.1 g / kg / hour (1 ml / kg / hour);
  • to replenish the loss of amino acids during a hemodialysis session – 0.2 g / kg / hour (2 ml / kg / hour).

Overdose
If the maximum allowed dose or the rate of administration of the solution is exceeded, as with an overdose of any amino acid solutions, chills, nausea, renal aminoacidosis, and vomiting may occur. Too high a rate of administration of the solution can cause a supersaturation of the body with fluid, an imbalance in the electrolyte balance. In this case, the introduction of the solution must be stopped immediately. Monitoring of biochemical parameters, appropriate treatment is required. Continuation of therapy is possible with low doses.

Side effects
Drugs were not observed with proper application.
Allergy development is possible.
With the introduction of the solution into the peripheral veins, the development of local side reactions is possible: phlebitis, hyperemia, thrombosis. Therefore, daily monitoring of the puncture site is recommended.

Storage conditions and periods
Nefrotect should be stored at temperatures ranging from +15 to + 25 ° C. Cannot be frozen. The shelf life of the solution is two years.