Neladex (neomycin, dexamethasone) eyes/ears drops 5 ml. vial

Description

Neladex composition and form of release
Active ingredients: neomycin (3.5 mg), dexamethasone (1 mg), polymyxin B sulfate (6000 ME).
Available as eye / ear drops.

Pharmacological properties
It is a combined topical anti-inflammatory and antibacterial agent. Neomycin is an aminoglycoside antibiotic that penetrates the bacterial cell membrane, binds to specific receptors on the 30S ribosome subunit and disrupts the process of protein synthesis, exerting a bacteriostatic effect (stops the growth and reproduction of bacteria). At higher concentrations, it damages the cytoplasmic membranes of microbial cells, causing their rapid death (bactericidal effect). Polymyxin B is an antibiotic of a polypeptide structure that binds to phospholipids of cell membranes, destroying them. Dexamethasone is a glucocorticoid agent that has a pronounced antiallergic, anti-inflammatory, desensitizing effect.

Indications
Neladex is used for infectious and inflammatory diseases of the eyes (with inflammation of the conjunctiva of the eyelids, cornea, bulbar conjunctiva, anterior segment of the eyeball, with chronic uveitis, damage to the cornea caused by radiation, chemical, thermal burns, foreign bodies).
Also used for acute / chronic otitis externa, acute otitis media (without perforation of the tympanic membrane).

Contraindications:

• with viral diseases of the cornea, conjunctiva (including chickenpox);
• with intolerance to the components of the drug;
• with keratitis caused by Herpes sіmplex (the causative agent of herpes simplex);
• with mycobacterial eye / ear infection;
• with a fungal infection of the eyes / ears;
• with tuberculosis;
• in violation of the integrity of the eardrum.

Application during pregnancy and lactation
Not applicable.

Method of administration and dosage
Neladex is intended for topical application (instillation into the eye / ear canal).
The number of instillations (instillations) is gradually reduced as the patient’s condition improves.
In milder forms of eye diseases, 1–2 drops are instilled into the conjunctival sac of the diseased eye 4–6 times / day. In severe forms, it is possible to use the medicine every hour (no more than 2 days). The standard course is 6-10 days.
For external otitis media – 1–5 drops in each ear x2 times / day.
The average duration of treatment is 7 days.

Overdose
Overdose symptoms: erythema, punctate keratitis, increased tearing, itching and swelling of the eyelids. Long-term and intensive use can cause systemic damage.

In case of overdose, the eye should be flushed with clean warm water to remove excess medication. Supportive, symptomatic therapy is carried out if necessary.

Side effects:

• Ophthalmic disorders: keratitis, blurred vision, increased intraocular pressure, photophobia, eye pain, mydriasis, ptosis of the eyelids, edema of the eyelids, discomfort in the eyes, itching, feeling of a foreign body in the eyes, dry eye syndrome, eye irritation, increased tearing, hyperemia ( redness) of the eyes, the formation of crusts at the edges of the eyelids, corneal erosion, thinning of the cornea, decreased visual acuity, changes in the field of vision, damage to the optic nerve, the formation of cataracts.
• Allergic manifestations: contact dermatitis (swelling, redness, itching, rash, irritation), angioedema, anaphylactic shock.
• Others: headache, dysgeusia (taste disturbances), dizziness,

Storage conditions and periods
Store Neladex drops in its original packaging (tightly closed) for no more than 2 years.
Temperature conditions: 15-25 ° С. After the first use, the drops are allowed to be stored for no more than 4 weeks.