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Nemotan is used: for the prevention / treatment of ischemic neurological disorders provoked by spasm of cerebral vessels due to subarachnoid hemorrhage (for example, with rupture of an aneurysm); for the treatment of functional disorders of brain activity (memory loss, impaired concentration, mood changes) in the elderly.
Description
Nemotan composition and form of release
Active ingredient: nimodipine.
Available in tablet form (30 mg).
Pharmacological properties
This drug is a selective calcium antagonist (blocks calcium channels) with a predominant effect on blood vessels. It has antispasmodic and vasodilating effects. Prevents the occurrence or eliminates vasospasm caused by prostaglandins, serotonin, histamine. Increases the flow of blood to the areas of the brain affected by impaired blood supply, especially after subarachnoid hemorrhage. It stabilizes the impaired functional state of neurons. The effect of this drug is manifested in a decrease in the severity of neurological symptoms provoked by cerebral ischemia.
Indications
Nemotan is used:
- for the prevention / treatment of ischemic neurological disorders provoked by spasm of cerebral vessels due to subarachnoid hemorrhage (for example, with rupture of an aneurysm);
- for the treatment of functional disorders of brain activity (memory loss, impaired concentration, mood changes) in the elderly.
Contraindications:
- with intolerance to the components;
- with severe liver failure;
- with cerebral edema;
- with an acute increase in intracranial pressure;
- with an attack of unstable angina pectoris;
- in the acute period of myocardial infarction and for a month after it.
It is also forbidden to use Nemotan in combination with rifampicin, antiepileptic drugs (phenobarbital, carbamazepine, phenytoin), as this leads to a significant decrease in the effectiveness of the drug.
Children
It is not used in pediatrics.
Application during pregnancy and lactation
During pregnancy, this drug is used in exceptional cases (the doctor determines the appropriateness of the appointment).
If necessary, use by women who are breastfeeding, stop feeding for the period of therapy.
Method of administration and dosage
Nemotan is used internally. The tablet is taken one hour before or two hours after a meal.
- The recommended dose after subarachnoid hemorrhage is 60 mg (two tablets) six times a day, while the interval between doses should be at least four hours. In the described dosage, the drug is taken for seven days, then the dose is gradually reduced. Duration of treatment is 21 days.
- The recommended dose for functional disorders of brain activity in the elderly is 30 mg (one tablet) three times a day. The duration of therapy is set individually (usually several months).
Overdose
In acute overdose, severe arterial hypotension (pressure drop), nausea, bradycardia or tachycardia, disruption of the gastrointestinal tract, signs of disruption of the central nervous system occur.
Side effects:
- Digestive disorders: diarrhea, nausea, dry mouth, change in appetite, paralytic intestinal obstruction.
- Neurological disorders: sleep disorders, dizziness, cephalalgia, psychomotor hyperactivity, hyperkinesis, aggressiveness, depression.
- Cardiovascular disorders: a drop in blood pressure (especially against the background of an initial increase in its level), hot flashes, hyperemia, a feeling of heat, bradycardia, increased sweating, bradycardia / tachycardia.
- Hematological disorders: thrombocytopenia.
- Immune disorders: allergic reactions.
- Changes in laboratory data: increased activity of transaminases, Lf, gamma-glutamyltransferase, changes in renal function indicators (increased concentration of urea, creatinine in plasma).
- Local reactions: phlebitis, thrombophlebitis.
Storage conditions and periods
It is necessary to store Nemotan at temperatures below +25 degrees Celsius for no more than 5 years. Parents must ensure the safety of their children by protecting their access to medication.
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