Nitrosorbid (isosorbide dinitrate) tablets 10 mg №40

Description

Nitrosorbid composition and form of release
Made in tablets. Each tablet contains 10 mg of isosorbide dinitrate.

Pharmacological properties
It is included in the group of peripheral vasodilators that affect venous and arterial vessels. The drug demonstrates a coronarolytic effect, reduces myocardial oxygen demand and helps to reduce venous spasm.

Indications
Nitrosorbid is used to prevent and treat angina attacks. In addition, it is also used in the complex therapy of chronic congestive heart failure.

Contraindications
Nitrosorbid is not indicated for patients with hypersensitivity to nitrate compounds. It is not prescribed for patients with acute vascular insufficiency, bleeding, hypovolemia, severe renal impairment, hepatic dysfunction, severe hypotension, hypertrophic obstructive cardiomyopathy, pericardial tamponade, constrictive pericarditis and cardiogenic shock in cases where it is impossible to correct the pressure of the end diastolic ventricle with intra-aortic counterpulsation or drugs with a positive inotropic effect.

Application during pregnancy and lactation
Due to insufficient knowledge of the effect of Nitrosorbid on the development of the fetus and the newborn, it is not used in the therapy of patients who are at the stage of pregnancy or breastfeeding.

Method of administration and dosage
The choice of dosage and duration of treatment is strictly individual.
Adult patients can take 10 to 20 mg of the drug 3 to 4 times a day. The drug is taken half an hour before meals. If the use of the drug in minimal doses does not allow achieving the desired therapeutic effect, then the dosage may be increased to 120 mg of the drug per day.
When prescribing the drug to patients suffering from congestive heart failure, continuous monitoring of hemodynamics is required.
The minimum interval between doses of the drug is 4 hours.
When using Nitrosorbid in the treatment of patients with reduced renal function or severe liver dysfunction, it is recommended to adjust the dosage downward.

Overdose
Taking high doses of the drug can cause in patients a significant decrease in blood pressure, weak pulse filling, pallor of the skin, increased sweating, reflex tachycardia, weakness, headache, dyspeptic disorders, seizures, orthostatic hypotension, visual disturbances.
To normalize the patient’s condition, it is necessary to urgently wash the stomach, lay the victim with a raised foot end, and ensure correct treatment. In severe cases, the administration of dopamine and sympathomimetics is indicated.

Side effects
Tachycardia, collapse, increased angina pectoris, orthostatic hypotension, fever, flushing, bradycardia, anxiety, headache, weakness, dizziness, lethargy, blurred vision, nausea, vomiting, narrowing of the visual field, and allergic reactions.

Storage conditions and periods
Nitrosorbid should be stored in places that are out of the reach of children and reliably protected from light and moisture. Duration of storage of funds – 2 years.