Nolpaza (pantoprazole) gastroresistive tablets 40 mg. №28

Description

Nolpaza composition
The active ingredient is pantoprazole sodium sesquihydrate 40 mg.

Release form
It is produced in the form of yellow-brown oval tablets, covered with an enteric coating.

Pharmacological properties
It is an antiulcer drug. The drug acts by inhibiting the proton pump of H + / K + -ATPase. When active molecules enter the tubular lumen of parietal cells, where the medium is acidic, they are oxidized, transforming into an active form. In this form, they bind the SH-groups of the H + / K + -ATPase, blocking (irreversibly) this enzyme. This disrupts the formation of hydrochloric acid (HCl), which is the main component of gastric juice.

Indications
Nolpaza is used in the treatment of gastroesophageal reflux disease, heartburn, sour regurgitation and pain when swallowing. In addition, the drug has proven its effectiveness in complex therapy in the eradication of Helicobacter pylori and gastric ulcer and intestinal ulcers caused by the intake of non-steroidal anti-inflammatory drugs. Nolpaza is indicated for the treatment of Zollinger-Ellison syndrome, as well as other pathological conditions that are associated with increased gastric secretion.

Contraindications
Cannot be used in the treatment of patients who suffer from dyspeptic disorders of neurotic etiology. Also, its use is unacceptable in case of hypersensitivity to the components of the drug.
When prescribing the drug, it is necessary to exclude the likelihood of the presence of malignant neoplasms in the patient, since the treatment can blur the clinical picture of the disease, which will not allow a timely diagnosis.

Children
It is not used in pediatrics.

Application during pregnancy and lactation
The experience of using the drug in the therapy of nursing and pregnant women is limited, and therefore, if it is necessary to use the drug during these periods, the necessary precautions should be taken.
The drug in the form of a lyophilisate is not used in the therapy of nursing and pregnant women.

Method of administration and dosage
Nolpaza can be taken once before breakfast or twice before morning and evening meals. In the treatment of heartburn, pain when swallowing and regurgitation with sour, 1 tablet of 20 mg should be taken for a mild disease and from 40 to 80 mg per day in a severe course of the disease. Positive dynamics in the clinical cratin of the disease becomes noticeable after 14 days of taking the drug. The maximum duration of treatment is 2 months. To prevent the development of relapses of the disease, the patient is prescribed the drug in a maintenance dosage. In addition, a one-time admission is possible in case of acute symptoms of dyspepsia.
In the treatment of ulcerative lesions of the stomach and intestines, caused by the intake of non-steroidal anti-inflammatory drugs, take 1 or 2 tablets of Nolpaza 40, for prophylactic purposes, the administration of Nolpaza 20 is indicated. The duration of treatment with Nolpaza is on average 30 days.

Overdose
Until recently, there were no cases of drug overdose.
When taking the drug in increased doses, the patient should flush the stomach and prescribe the intake of activated charcoal. In especially difficult cases, symptomatic therapy is recommended.

Side effects
When taking the drug, patients may complain of abdominal pain, stool disturbance, flatulence, dry mouth mucous membranes, nausea, vomiting, dizziness, visual impairment, peripheral edema and depression. In addition, patients with hypersensitivity to the drug may experience various allergic reactions, manifested by itching, skin rashes, hyperemia and anaphylactic shock.

Storage conditions and periods
Nolpaza should be stored in places that are out of the reach of children and protected from light. The duration of storage of the tablets – 5 years.