Description

Ogrania (pregabalin) capsules 300 mg. №30

Ingredients

Active ingredient: Pregabalin 300 mg.

Dosage

Dosage: The usual dose of Ogrania (pregabalin) capsules is 300 mg taken orally once daily.

Indications

Indications: Ogrania (pregabalin) capsules are indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, and spinal cord injury.

Contraindications

Contraindications: Ogrania (pregabalin) capsules are contraindicated in patients with known hypersensitivity to pregabalin.

Directions

Directions: Swallow the capsules whole with water. It can be taken with or without food.

Scientific Evidence

Pregabalin’s efficacy: Studies have shown that pregabalin is effective in reducing neuropathic pain and improving quality of life in patients with various neuropathic pain conditions. Research by Rosenstock et al. (2004) demonstrated significant pain relief with pregabalin compared to placebo in diabetic neuropathy.

Additional Information

Pregabalin exerts its pharmacological effects by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, modulating calcium influx and inhibiting the release of excitatory neurotransmitters. This mechanism of action contributes to its analgesic and anticonvulsant properties.

Clinical trials have shown that pregabalin is well-tolerated and effective in the management of neuropathic pain, with a favorable safety profile. Compared to other medications, pregabalin has demonstrated comparable or superior efficacy in certain neuropathic pain conditions, making it a valuable treatment option.