Oliclinomel №7-1000E suspension for infusions 1500 ml. №4

Description

Oliclinomel №7-1000E composition
Main active ingredients: a mixture of refined olive and soybean oils, L-alanine, L-arginine, glycine, L-histidine, L-isoleucine, L-leucine, L-lysine (as L-lysine hydrochloride), L-methionine, L -phenylalanine, L-proline, L-serine, L-threonine, L-tryptophan, L-tyrosine, L-valine, sodium acetate trihydrate, sodium glycerophosphate pentahydrate, potassium chloride, magnesium chloride hexahydrate; anhydrous glucose, calcium chloride dihydrate, electrolytes (sodium, potassium, magnesium, calcium, phosphate, chloride, acetate), lipids, amino acids, hydrocarbons, nitrogen.
Auxiliary components – citric acid monohydrate, egg lecithin, glycerin, sodium oleate, sodium hydroxide, water for injection.

Release form
This drug is available in the form of an emulsion for infusion, 300 ml of 20% lipid emulsion, 600 ml of a 10% solution of amino acids with electrolytes and 600 ml of a 40% solution of glucose with calcium in a three-chamber plastic bag with a volume of 1500 ml.

Pharmacological properties
This drug Oliclinomel №7-1000E belongs to a group of drugs that are used for parenteral nutrition, which include amino acids, fats, carbohydrates, electrolytes.
It is especially recommended for patients who need an increased dose of protein, fats, glucose for energy, in particular, in the treatment and prevention of protein deficiency after surgery, injuries, burns, ENT practice, and other cases when enteral nutrition is impossible.
In particular, it contains glucose as an energy source for amino acid metabolism. Amino acids, in turn, play an important role in protein synthesis.
Since the composition of the drug, in addition to glucose, includes a lipid emulsion, its use reduces the risk of thrombophlebitis.
This is especially important, since the risk of its occurrence is exacerbated if the patient is shown the introduction of hypertonic solutions into the peripheral veins.

Indications
This medicinal product Oliclinomel №7-1000E is used for parenteral nutrition of both adults and children, when oral or enteral nutrition is not possible, insufficient or contraindicated.
Recommended for patients with moderate to severe catabolism.

Contraindications
Not applicable if the patient has hypersensitivity (allergy) to one of the components that make up the drug.
Also contraindicated for:

• severe hyperlipidemia;
• severe liver failure;
• severe blood clotting disorders;
• congenital disorders of amino acid metabolism;
• severe renal failure in the absence of hemodialysis or hemofiltration;
• the period of the acute phase of shock;
• hyperglycemia, requiring the introduction of insulin in an amount of more than 6 U / h;
• pathologically increased concentration in blood plasma of any of the electrolytes included in the preparation;
• general contraindications to infusion therapy;
• unstable conditions (including post-traumatic conditions, diabetes mellitus, myocardial infarction, etc.);
• hemophagocytic syndrome.

The drug should be used with caution in patients suffering from disorders in the blood coagulation system and in patients with anemia.

Children
In pediatrics, it can be used after reaching 2 years of age.

Application during pregnancy and lactation
Treatment of pregnant women with this drug is contraindicated.
During treatment, lactation should be suspended.

Method of administration and dosage
Oliclinomel №7-1000E is intended exclusively for intravenous administration into central veins.
The dosage and rate of infusion are prescribed by the doctor on an individual basis and are determined by the patient’s ability to excrete lipids and metabolize glucose.
Infusion of Oliclinomel №7-1000E can be continued for as long as required by the patient’s clinical condition, based on the daily requirement for glucose, lipids and amino acids.
The dose should be selected individually and, when choosing the size of the bag, take into account the patient’s condition, body weight and the need for nutrients.
The maximum daily dosage is 75 ml per 1 kg of body weight, no more than 3 g per 1 kg of body weight per hour.
The daily dose for children aged 2-11 years is 60-110 kcal per 1 kg of body weight.

Overdose
Overdose can manifest itself as:

• feelings of heat;
• tachycardia;
• pulmonary edema;
• imbalance of electrolytes;
• lipid overload.

This condition can also be observed at the recommended infusion rate if the patient’s clinical condition changes dramatically and severe renal or hepatic failure develops.
Treatment: cessation of lipid infusion, symptomatic therapy, hemodialysis.

Side effects
Most often, the drug is well tolerated. In some cases, when a hypersensitivity reaction occurs, side effects are also possible, such as:

• allergic reactions (anaphylactic shock (rare), fever, chills, tremors, skin rash, allergic urticaria);
• breathing changes (tachypnea);
• arterial hypertension, arterial hypotension;
• increased activity of liver enzymes;
• hemolysis;
• reticulocytosis;
• abdominal pain, headache;
• hyperglycemia, metabolic acidosis;
• shortness of breath, cyanosis.

If you experience any unusual side effects as a result of taking this drug, you should consult your doctor about possible changes in the treatment regimen.

Storage conditions and periods
The shelf life of the drug is no more than 2 years from the production date indicated on the package.
This medicinal product should be stored in a dry place out of the reach of children, at a temperature not exceeding 25 ° C.
The introduction is carried out immediately after preparation of the solution. If the drug is not used immediately, then this solution can be stored for 7 days at a temperature of 2-8 ° C.
After mixing the contents of three chambers, the drug retains its properties for 48 hours, at a temperature not exceeding 25 ° C.