Description

Omeprazol Lyophilisate for Solution for Infusions 40 mg. №1 Vial

Ingredients

Active ingredient: Omeprazole
Other ingredients: Mannitol, sodium hydroxide, and hydrochloric acid.

Dosage

Dosage: The recommended dose is 40 mg once daily via intravenous infusion over a period of 20-30 minutes.

Indications

Indications: Omeprazol lyophilisate is indicated for the treatment of gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.

Contraindications

Contraindications: Do not use in patients with known hypersensitivity to omeprazole or any of the excipients. Not recommended for use during pregnancy or lactation.

Directions

Administration: Administer as an intravenous infusion only by healthcare professionals. Follow the recommended dosage and infusion rate strictly.

Scientific Evidence

Omeprazole, the active ingredient in Omeprazol lyophilisate, is a proton pump inhibitor that works by reducing the production of stomach acid. Several studies have demonstrated the efficacy of omeprazole in the treatment of acid-related disorders. For example, a study published in the Journal of Gastroenterology showed that omeprazole was highly effective in healing peptic ulcers and preventing their recurrence.

Additional Information

It is important to monitor for any signs of allergic reactions or adverse effects during omeprazole infusion. Patients with liver impairment may require dosage adjustments. Consult with a healthcare provider for personalized dosing recommendations.

Pharmacological Effects

Omeprazole inhibits the enzyme H+/K+ ATPase in the gastric parietal cells, thereby reducing the secretion of gastric acid. This results in a decrease in gastric acidity, promoting the healing of ulcers and providing relief from symptoms of acid reflux.

Clinical Trials and Comparative Effectiveness

Clinical trials have shown omeprazole to be as effective as other proton pump inhibitors in the treatment of acid-related disorders. A meta-analysis published in the American Journal of Gastroenterology compared the efficacy of omeprazole with other PPIs and found no significant difference in healing rates of peptic ulcers.

Overall, Omeprazol lyophilisate for solution for infusions 40 mg. №1 vial is a well-established medication with proven efficacy in the management of acid-related disorders.