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Omeprazol is prescribed: with peptic ulcer of the duodenum, stomach (for the treatment or prevention of relapse); with reflux esophagitis; with gastroesophageal reflux disease; with NSAID-associated gastropathy – changes in the walls of the stomach caused by the use of non-steroidal anti-inflammatory drugs; with acute pancreatitis (to exclude the secretory activity of the gland); with hypersecretory conditions (polyendocrine adenomatosis, Zollinger-Ellison syndrome, stress ulcer, systemic mastocytosis); in the schemes of eradication of Helicobacter pylori.
Description
Omeprazol composition and form of release
Active ingredient: omeprazole (20 mg).
Available in capsule form.
Pharmacological properties
Omeprazol is a proton pump inhibitor. The drug is concentrated in the secretory tubules of the parietal cells of the inner lining of the stomach. In an acidic environment, it is activated, inhibits the enzyme H +, K + -ATPase (proton pump), affecting the last stage of the production of hydrochloric acid in the stomach.
Indications
Omeprazol shown:
- with duodenal ulcers;
- with NSAID-associated ulcers, erosions of the stomach and / or duodenum;
- with stomach ulcers;
- for the eradication of Helicobacter pylori (in peptic ulcer treatment regimens);
- with reflux esophagitis;
- with symptomatic gastroesophageal reflux disease;
- with dyspepsia associated with hyperacid conditions (high acidity);
- with Zollinger-Ellison syndrome.
Contraindications:
with intolerance to the components.
Used with caution:
- in the presence of such disorders as frequent vomiting, significant weight loss (spontaneous), melena, dysphagia, vomiting of blood;
- if a malignant neoplasm of the stomach is suspected (since treatment can mask its manifestations and delay the diagnosis).
Children
It is used in pediatrics for children over 12 years old.
Application during pregnancy and lactation
It can be applied.
Method of administration and dosage
Omeprazol is administered orally (preferably in the morning).
- The standard dose for duodenal ulcers is 20 mg once a day. Ulcer healing occurs, as a rule, within 2 weeks. If there is no effect during this period, the drug is indicated for the next 2 weeks. Patients with a resistant ulcer are given 40 mg once daily for four weeks.
- To prevent recurrence of duodenal ulcers, a maintenance dose is recommended – 10 mg per day, if necessary – 20-40 mg once a day.
- The standard dose for stomach ulcers is 20 mg per day for four weeks. In the absence of a therapeutic effect during this period, the drug is indicated for the next 4 weeks. Patients with a resistant ulcer are given 40 mg daily for eight weeks. To prevent recurrence of gastric ulcers, a maintenance dose is recommended – 20 mg per day, if necessary – 40 mg once a day.
- The standard dose for NSAID-associated ulcers, gastric and / or duodenal erosions, gastroduodenal erosions is 20 mg per day for four weeks. If there is no effect during this period, the drug is indicated for the next 4 weeks. For the prevention of ulcers, erosions of the stomach and / or duodenum, a dose of 20 mg per day is recommended.
- The standard dose for reflux esophagitis is 20 mg per day for four weeks. If there is no effect during this period, the drug is indicated for the next 4 weeks. For severe reflux esophagitis, 40 mg daily is recommended for eight weeks. In the stage of remission, 10 mg per day is shown in the form of long courses. If necessary, the dose is increased to 20-40 mg.
- The standard dose for symptomatic gastroesophageal reflux disease is 20 mg per day. If after four weeks of taking the symptoms do not disappear, an additional examination of the patient is recommended.
- The standard dose for dyspepsia associated with hyperacid conditions is 10-20 mg per day. If after four weeks of taking the symptoms do not disappear, an additional examination of the patient is recommended.
- With Zollinger-Ellison syndrome, the dose is selected individually (20-120 mg). Treatment is continued as needed – 60 mg daily. If the daily dose is above 80 mg, it is divided into two parts.
Overdose
Symptoms: confusion, dizziness, apathy, vascular dilatation, headache, tachycardia, vomiting, diarrhea, flatulence.
Treatment for overdose: gastric lavage, intake of adsorbents, symptomatic therapy.
Side effects
The following reactions are possible: abdominal pain, headache, diarrhea, flatulence, constipation, nausea / vomiting, itching, rash, dermatitis, urticaria, drowsiness, paresthesia, insomnia, dizziness, malaise, allergies (fever, angioedema, anaphylactic shock) hepatitis, hepatic failure, bronchospasm, encephalopathy, arthralgia, muscle weakness, myalgia, leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, hyponatremia, depression, agitation, hallucinations, aggression, confusion, taste disturbance, erythrocyte, stomatitis, indigestion photosensitization, alopecia, toxic epidermal necrolysis, sweating, interstitial nephritis, dry mouth, Stevens-Johnson syndrome, gynecomastia, microscopic colitis, peripheral edema, hypomagnesemia, hypokalemia, hypocalcemia.
Storage conditions and periods
Store at temperatures up to + 25 ° С for no more than 2 years.
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