Description

Otrivin (Xylometazoline Hydrochloride) Drops 0.1% 10 ml

Ingredients

Active ingredient: Xylometazoline hydrochloride 0.1% w/v. Inactive ingredients: Benzalkonium chloride, sodium dihydrogen phosphate dihydrate, disodium phosphate dodecahydrate, sodium chloride, sorbitol, and purified water.

Dosage

Adults and children over 12 years: 1-2 drops into each nostril 2-3 times daily. Do not exceed the recommended dosage.

Indications

Otrivin Drops 0.1% are indicated for the relief of nasal congestion associated with allergic rhinitis, sinusitis, and colds.

Contraindications

Do not use Otrivin Drops 0.1% if you have: hypersensitivity to xylometazoline or any other ingredients, rhinitis sicca, narrow-angle glaucoma, or after trans-sphenoidal hypophysectomy.

Directions

For nasal use: Tilt head forward, insert dropper into nostril, and squeeze the dropper to release the solution. Breathe in gently through the nose and repeat for the other nostril.

Scientific Evidence

Xylometazoline hydrochloride, the active ingredient in Otrivin Drops, is a selective alpha-1 adrenergic receptor agonist. It works by constricting blood vessels in the nasal passages, reducing swelling and congestion. Studies have shown that xylometazoline provides rapid relief from nasal congestion with a duration of action of up to 12 hours (Smith et al., 2018).

Additional Information

It is important to follow the recommended dosage and not use Otrivin Drops for more than 7 consecutive days to avoid rebound congestion. Consult a healthcare professional before use if you are pregnant, breastfeeding, or have any underlying medical conditions.

Pharmacological studies have demonstrated that xylometazoline acts locally on the nasal mucosa, leading to vasoconstriction and reduced nasal blood flow. This results in decreased nasal congestion and improved airflow, providing relief to individuals suffering from nasal congestion due to various causes.

Clinical trials comparing xylometazoline with other nasal decongestants have shown its efficacy in providing fast and long-lasting relief from nasal congestion without significant systemic side effects. Its safety profile and effectiveness make it a popular choice for managing nasal congestion in both adults and children.