Description
Papaverin Hydrochloride Solution for Injection 2% 2 ml. №10 Vials
Ingredients:
Each 2 ml vial contains 2% Papaverin hydrochloride solution for injection.
Dosage:
The dosage should be determined based on individual needs and is typically administered by injection into a muscle or vein as directed by a physician.
Indications:
- Papaverin hydrochloride solution is indicated for the treatment of smooth muscle spasms.
- Commonly used to relieve spasms in the gastrointestinal tract, urinary system, and blood vessels.
Contraindications:
Do not use Papaverin hydrochloride solution if allergic to any of the ingredients or in patients with severe hypotension or certain heart conditions.
Directions:
Administer the injection as directed by a healthcare provider and do not exceed the recommended dosage.
Scientific Evidence:
Papaverin hydrochloride acts as a smooth muscle relaxant by inhibiting phosphodiesterase, leading to vasodilation and decreased smooth muscle contractions. Studies have shown its efficacy in reducing spasms in various organs and systems.
Additional Information:
- Store as directed and keep out of reach of children.
- Contact your healthcare provider immediately if you experience adverse reactions.
Pharmacological Effects: Papaverin hydrochloride acts as a smooth muscle relaxant by inhibiting the enzyme phosphodiesterase, leading to an increase in intracellular cyclic adenosine monophosphate (cAMP). This results in vasodilation and decreased smooth muscle contractions.
Clinical Trials: Clinical trials have demonstrated the effectiveness of Papaverin hydrochloride in conditions like biliary colic, renal colic, and peripheral vascular diseases. A study in the Journal of Gastroenterology and Hepatology showed improvement in irritable bowel syndrome symptoms with Papaverin hydrochloride injections.
