Penicillin G sodium chloride for injections 1 mln IU №100 vial

Description

Penicillin G sodium chloride release form, composition
White powder for preparation of an injection, which is sealed in vials, the vials are packed in a cardboard box, 100 vials in each pack.
Composition of the medicine: 1,000,000 IU of benzylpenicillin sodium salt.

Pharmacological properties                                                                                                                                                 Penicillin G sodium chloride is a water-soluble benzylpenicillin that has a bactericidal effect on sensitive microorganisms by inhibiting cell wall biosynthesis by blocking penicillin-binding proteins. Resistance / Resistance to benzylpenicillin can be observed in the following cases: beta-lactamase inactivation: benzylpenicillin is sensitive to beta-lactamase and therefore inactive against beta-lactamase-producing bacteria (eg staphylococci or gonococci); Decreased affinity of penicillin-binding proteins for benzylpenicillin: Acquired resistance to pneumococci and several other streptococci to benzylpenicillin is due to changes in existing penicillin-binding proteins as a result of mutations. However, the formation of additional penicillin-binding proteins with reduced affinity for benzylpenicillin is the result of resistance to methicillin (oxacillin) resistant staphylococci; in gram-negative bacteria, insufficient penetration of penicillin through the outer cell wall can lead to insufficient inhibition of penicillin-binding proteins; benzylpenicillin can be actively transported from the cell by efflux pumps; benzylpenicillin is partially or completely cross-resistant to other penicillins and cephalosporins.

Indication                                                                                                                                                            Infectious diseases caused by penicillin-sensitive microorganisms: sepsis, wound and skin infections, diphtheria (as an antitoxin supplement), pneumonia, empyema, erysipeloid, pericarditis, bacterial endocarditis, mediastinitis, peritositis, peritonitis, menitositis, menitositis, peritonitis, menitositis caused by fusobacteria, as well as in specific infections: anthrax; infections caused by clostridia, including tetanus, listeriosis, pasteurellosis; fever caused by rat bites; fusospirochetosis, actinomycosis; treatment of complications caused by gonorrhea and syphilis, Lyme borreliosis after the first stage of the disease.

Contraindications
Contraindications for use are: bronchial asthma, infectious mononucleosis, liver failure, lymphocytic leukemia, anemia, hypersensitivity to the composition, namely to components that can cause allergic reactions or other negative reactions of the body to the drug in a sick patient.

Pregnancy and breastfeeding period
Mothers and pregnant women are advised to consult a doctor for advice before starting to use the medication, as there may be risks for the baby or the mother’s health. If the use of the drug is safe for your health and the health of your baby, then taking it is possible.

Mode of application
For each drug there is a certain dosage, which is prescribed by the attending specialist after determining the diagnosis of a sick patient, therefore, before using it, it is recommended to go to the doctor for advice and instructions on taking the drug.
The typical dose for this drug Penicillin G sodium chloride is as follows: the drug must be administered intravenously or intramuscularly, up to 1,000,000-5,000,000 IU per day, but no more than 5,000,000 IU per day, so as not to exceed the dosage and prevent side effects. The period of treatment for each patient is different, and is determined by the doctor for the patient individually.

Overdose
If a sick patient has exceeded the dosage assigned to him by the attending specialist, then the patient has a manifestation of allergic reactions of the body, and there is also an increase in adverse reactions to the components that make up the composition.

Adverse reactions
The negative, namely, side effects that appear in a sick patient include the following reactions: nausea, vomiting, headache, dizziness, thrombocytopenia, leukopenia, black plaque on the tongue, violation of taste buds, allergic reactions – redness of the skin, skin itching , skin rash; agranulocytosis, immunopathological reactions.

Storage conditions
The drug Penicillin G sodium chloride is stored at a temperature not exceeding + 25 ° C, while the place where the drug is stored must be very dry and dark and out of reach of children to avoid negative results.
The shelf life of a medicinal product lasts for 60 months from the production date that is on each package of the medicine.