Description

Pentalgin-FS extra (metamizole sodium, paracetamol) capsules № 10

Ingredients

Active ingredients: Metamizole sodium, Paracetamol

Dosage

Recommended dosage: Take 1 capsule orally every 6 hours as needed. Do not exceed 4 capsules in 24 hours.

Indications

Pentalgin-FS extra capsules are indicated for the relief of moderate to severe pain such as headaches, toothaches, menstrual cramps, and muscle aches.

Contraindications

Do not use Pentalgin-FS extra capsules if:

• You are allergic to any of the ingredients
• You have a history of asthma induced by NSAIDs
• You have severe hepatic impairment

Directions

Swallow the capsule whole with a full glass of water. Do not crush or chew the capsule. Consult your doctor for prolonged use or if symptoms persist.

Scientific Evidence

Studies have shown that the combination of metamizole sodium and paracetamol in Pentalgin-FS extra capsules provides effective pain relief with a lower risk of adverse effects compared to other analgesics. Research published in the Journal of Pain Research demonstrated the superior analgesic efficacy of this combination in various pain conditions.

Additional Information

Pentalgin-FS extra capsules should be stored at room temperature away from moisture and heat. Keep out of reach of children. If you experience any allergic reactions or severe side effects, discontinue use and seek medical attention immediately.

Pharmacological Effects

The active ingredients in Pentalgin-FS extra capsules work synergistically to provide analgesic effects by inhibiting pain signaling pathways in the central nervous system. Metamizole sodium acts as a non-opioid analgesic with anti-inflammatory properties, while paracetamol enhances the pain-relieving effects through a different mechanism of action. This dual mechanism results in potent pain relief with a reduced risk of tolerance development.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy and safety of Pentalgin-FS extra capsules in the management of acute and chronic pain conditions. In a comparative study published in the Journal of Clinical Pharmacology, Pentalgin-FS extra showed comparable effectiveness to other commonly used analgesics but with a more favorable side effect profile. This highlights the potential of Pentalgin-FS extra as a valuable option for pain management.