Pimafucin (natamycin) vaginal suppositories 100 mg. №6

Description

Pimafucin composition and form of release
The active ingredient is natamycin. It is produced in the form of vaginal suppositories, which is intended for topical use.

Pharmacological properties
Natamycin is a fungicidal agent. It irreversibly binds to steroids of the cell membrane, contributing to the dysfunction and integrity of the latter, thus destroying microorganisms. A large number of yeast fungi, yeast-like organisms, dermatophytes and fungi are sensitive to natamycin. The average minimum fungicidal concentration (MFC) is 1-10 μg / ml for most microorganisms, including strains of Candida albicans, the most common pathogen that causes fungal infections. Natamycin is inactive against bacteria. In clinical practice, there have been no cases of primary resistance of yeast, fungi and yeast-like microorganisms.

Indications
Local antimicrobial antiseptic drug Pimafucin. It is used to treat infections of fungal etiology that are caused by a microflora that is sensitive to the drug, in particular, with candidal vulvovaginitis caused by various pathogenic fungi, and in particular with the yeast Candida albicans, which is most often the cause of infection of the genital organs.
The use of Pimafucin suppositories is more effective as part of the complex treatment of systemic fungal infections, together with its tablet form.
It is a polyene antibiotic, acting fungicidal, binding sterols of cell membranes, disrupting their integrity, which causes the death of microorganisms. Does not cause resistance or systemic allergy, does not have a sensitizing effect.
Pimafucin is distinguished by its ability to provide a therapeutic effect even with vaginal discharge, inflammation and itching, including the least accessible upper vagina.
It does not enter the bloodstream, as a result, it does not have a systemic effect.

Contraindications
Not prescribed for hypersensitivity to natamycin.

Application during pregnancy and lactation
Pimafucin can be used in the treatment of pregnant and lactating women, as there is no evidence that it can adversely affect the development of the fetus or breastfed baby of the mother receiving treatment with this drug.

Method of administration and dosage
Suppositories are used in the treatment of vulvovaginal candidiasis. Suppositories are inserted deep into the vagina once a day before going to bed. Suppositories are inserted in a horizontal position.
The duration of treatment can be from 3 to 6 days. After the clinical symptoms of the disease disappear, treatment is continued for another 2 or 3 days.
Does not require cancellation for menstrual bleeding. There is no need to interrupt sex during treatment, but barrier protection is recommended.
Melting quickly in the vaginal area, it creates a foaming mass that promotes an even and complete distribution of the active substance over the entire surface inside the vagina.

Overdose
Due to the fact that this pharmaceutical product has low adsorption, the possibility of overdose is practically excluded.

Side effects
With the local use of suppositories with natamycin, the patient may experience a burning sensation and itching, mild hyperemia, which pass on their own and do not require discontinuation of the drug.

Storage conditions and periods
Stored up to 4 years at temperatures up to 25 ° C.