Piofag solution 50 ml. vial №1

Description

Piofag composition
active substance: 1 ml of the drug contains specific bacteriophages in a concentration of at least 1 × 105 phage particles to the following species of microorganisms: Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Proteus mirabilis;
excipients: sodium chloride; magnesium chloride hexahydrate; sodium hydroxide; dilute hydrochloric acid; water for injections.

Dosage form
Solution.

Pharmacological properties
Immunobiological and biological properties of the drug Piofag has the ability to specifically lyse bacteria such as Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Proteus mirabilis. Bacteriophages specifically infect bacterial cells, multiply inside the bacterial cell and destroy it by lysis. The antibacterial effect of the drug is due to the specific lysis of pathogenic bacteria, while the drug does not disrupt the normal microflora. Under the action of bacteriophage, phagocytosis is activated, the activity of neutrophils and their metabolic activity increases, which prevents the recurrence of infectious disease and chronic inflammatory process. The number of leukocytes and neutrophils decreases, and the level of lymphocytes increases mainly due to T-lymphocytes. Bacteriophages enter the blood and lymph in a short time and are excreted by the kidneys in the urine.

Indication
Treatment and prevention of purulent-inflammatory and intestinal diseases caused by staphylococci, streptococci, Pseudomonas aeruginosa, Escherichia coli of various serogroups, Proteus. Piofag is used as monotherapy or as part of a combination treatment.

Contraindication
Hypersensitivity to the components of the drug.

Use during pregnancy or breastfeeding
Safety and efficacy have not been established, so use is contraindicated.

Method of application and dosage
Treatment of purulent-inflammatory diseases with localized lesions should be carried out both locally and orally. The duration of treatment is 7-20 days.
The instructions for medical use should be followed when dosing Piofag. In case of small doses (2-8 drops), the drug should be collected with a sterile syringe with a volume of 0.5-1 ml or use a spray nozzle. 1 milliliter of the drug contains 20 drops of bacteriophage solution, 1 injection of a spray nozzle contains 0.2 ml of solution.

• Topically applied in the form of irrigation, lotions and tamponade with liquid phage in an amount of up to 200 ml depending on the size of the affected area. At abscesses the bacteriophage is entered into a center of the center after removal of pus by means of a puncture. The amount of drug administered should be slightly less than the amount of manure removed. In osteomyelitis, after appropriate surgical treatment, 10-20 ml of bacteriophage is poured into the wound.
• Introduction into the cavities – pleural, articular and other limited cavities – up to 100 ml of bacteriophage, then leave the capillary drainage, through which for several days re-injected bacteriophage.
• At cystitis, pyelonephritis, urethritis the drug is taken orally. If the cavities of the bladder or renal pelvis are drained, the bacteriophage is injected through a cystostomy or nephrostomy 1-2 times a day, 20-50 ml into the bladder and 5-7 ml into the renal pelvis.
• In purulent-inflammatory gynecological diseases, the drug is injected into the vaginal cavity, uterus in a dose of 5-10 ml once a day.
• In purulent-inflammatory diseases of the ear (otitis), throat (sore throat), nose, the drug is administered in a dose of 2-10 ml 1-3 times a day. Bacteriophage is used for rinsing, washing, instillation, wetting turund (which is injected and left for 1 hour).
• With conjunctivitis and keratoconjunctivitis, the drug is instilled 2-3 drops 4-5 times a day, with purulent corneal ulcers – 4-5 drops, with purulent iridocyclitis, the drug is used 6-8 drops every 3 hours in combination with orally.
• In the treatment of stomatitis and chronic generalized periodontitis, the drug is used in the form of mouth rinses 3-4 times a day at a dose of 10-20 ml, and also injected into periodontal pockets turundy impregnated with the drug for 5-10 minutes.
• In intestinal forms of the disease, diseases of internal organs, dysbacteriosis, the drug is used orally and in enemas. Orally bacteriophage is taken 3 times a day on an empty stomach 1 hour before meals.

The recommended dosage of the drug when used orally:

• Up to 6 months – 5 ml;
• From 6 to 12 months – 10 ml;
• From 1 to 3 years – 15 ml;
• From 3 to 8 years – 20 ml;
• From 8 years – 30 ml.

The use of bacteriophages does not preclude the use of other antibacterial drugs. If chemical antiseptics have been used to treat wounds before bacteriophage is used, the wound should be rinsed thoroughly with sterile 0.9% sodium chloride solution.
In intestinal forms of the disease, rectal administration of bacteriophage is possible – once a day, in the form of an enema after bowel movement instead of 1 oral administration.

The use of bacteriophages does not preclude the use of other antibacterial drugs. If chemical antiseptics have been used to treat wounds before bacteriophage is used, the wound should be rinsed thoroughly with sterile 0.9% sodium chloride solution.
In intestinal forms of the disease, rectal administration of bacteriophage is possible – once a day, in the form of an enema after bowel movement instead of 1 oral administration.

The recommended dosage of the drug when applied rectally:

• Up to 6 months – 10 ml;
• From 6 to 12 months – 20 ml;
• From 1 to 3 years – 30 ml;
• From 3 to 8 years – 40 ml;
• From 8 years – 50 ml.

For prophylactic purposes, the optimal schedule is daily oral administration of a single age dose. The duration of application is determined by the conditions of the epidemic situation.

Children
The drug Piofag is intended for use in children.

Overdose
Cases of drug overdose are not described.

Side effects
Cases of adverse reactions are not described.

Expiration date
3 years.

Storage conditions
Store at a temperature of 2 to 8 ° C in the original package. After the first opening of a bottle storage no more than 10 days at a temperature from 2 to 8 ° C is possible. Transportation is allowed at a temperature not exceeding 25 ° C for not more than 30 days, then the drug is stored at a temperature of 2 to 8 ° C.

Incompatibility
Do not mix with other drugs.