Description

Prestarium Argynin Combi Coated Tablets 5/1,25 mg. №30

Ingredients

Each coated tablet contains 5 mg of perindopril arginine and 1.25 mg of indapamide.

Dosage

The recommended dosage is one tablet per day, preferably in the morning before a meal.

Indications

Prestarium Argynin Combi is indicated for the treatment of hypertension in patients whose blood pressure is not adequately controlled by perindopril alone.

Contraindications

Do not use Prestarium Argynin Combi if you are allergic to perindopril, indapamide, or any other ingredients in the product. It is also contraindicated in patients with severe renal impairment.

Directions

Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.

Scientific Evidence

Studies have shown that the combination of perindopril and indapamide in Prestarium Argynin Combi provides better blood pressure control compared to monotherapy with perindopril alone.

Additional Information

It is important to monitor electrolyte levels and renal function regularly while taking Prestarium Argynin Combi, especially in elderly patients and those with pre-existing renal conditions.

Pharmacological Effects: Perindopril is an ACE inhibitor that works by blocking the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced aldosterone secretion. Indapamide is a thiazide-like diuretic that promotes diuresis and vasodilation, further lowering blood pressure.

Clinical Trials: In a randomized controlled trial by Williams et al., the combination of perindopril and indapamide was found to significantly reduce the incidence of cardiovascular events in patients with hypertension compared to placebo.