Description
Prestarium Argynin Combi Coated Tablets 5/1.25 mg. №30
Ingredients
- Each coated tablet contains 5 mg of perindopril arginine and 1.25 mg of indapamide.
Dosage
- The recommended dosage is one tablet per day, preferably in the morning before a meal.
Indications
- Prestarium Argynin Combi is indicated for the treatment of hypertension in patients whose blood pressure is not adequately controlled by perindopril alone.
Contraindications
- Do not use Prestarium Argynin Combi if you are allergic to perindopril, indapamide, or any other ingredients in the product. It is also contraindicated in patients with severe renal impairment.
Directions
- Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.
Scientific Evidence
- Studies have shown that the combination of perindopril and indapamide in Prestarium Argynin Combi provides better blood pressure control compared to monotherapy with perindopril alone.
Additional Information
- It is important to monitor electrolyte levels and renal function regularly while taking Prestarium Argynin Combi, especially in elderly patients and those with pre-existing renal conditions.
Pharmacological Effects
- Perindopril is an ACE inhibitor that works by blocking the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced aldosterone secretion. Indapamide is a thiazide-like diuretic that promotes diuresis and vasodilation, further lowering blood pressure.
Clinical Trials
- In a randomized controlled trial by Williams et al., the combination of perindopril and indapamide was found to significantly reduce the incidence of cardiovascular events in patients with hypertension compared to placebo.
