Description

Prograf (tacrolimus) hard capsules 0.5 mg. №50

Ingredients

Active ingredient: Tacrolimus

Other ingredients: Lactose monohydrate, croscarmellose sodium, hypromellose, and magnesium stearate.

Dosage

Dosage: The usual starting dose of Prograf is 0.1 to 0.15 mg/kg/day, divided into two doses. Dosage may vary based on individual patient factors.

Indications

Indications: Prograf is indicated for the prophylaxis of organ rejection in patients receiving allogeneic liver, kidney, or heart transplants.

Contraindications

Contraindications: Prograf is contraindicated in patients with a hypersensitivity to tacrolimus or any component of the formulation.

Directions

Directions: Take Prograf exactly as prescribed by your healthcare provider. Swallow the capsules whole with a full glass of water. Do not crush or chew the capsules.

Scientific Evidence

Tacrolimus, the active ingredient in Prograf, is a calcineurin inhibitor that suppresses the immune system by inhibiting T-lymphocyte activation. This mechanism of action helps prevent organ rejection in transplant patients. Several studies have demonstrated the efficacy of tacrolimus in improving transplant outcomes and reducing rejection rates.

Additional Information

It is essential to monitor tacrolimus blood levels regularly to ensure therapeutic efficacy and avoid toxicity. Common side effects of Prograf include tremors, hypertension, and renal dysfunction. Patients should be closely monitored for these adverse effects during treatment.

Prograf has been extensively studied in clinical trials, showing its effectiveness in preventing organ rejection and improving patient survival rates post-transplant. Research has also highlighted the importance of individualized dosing based on patient characteristics to optimize outcomes and minimize side effects.