Description

Protamin solution for injections 1000ME/ml. 5 ml. vial №5

Ingredients

Each ml contains 1000ME of Protamin sulfate.

Dosage

The recommended dosage is determined by the healthcare provider based on the individual’s condition. It is typically administered via injection into a vein or muscle.

Indications

Protamin solution is indicated for the reversal of heparin anticoagulation. It is used in surgical procedures where heparin needs to be neutralized quickly.

Contraindications

Do not use Protamin solution if there is a known hypersensitivity to protamine sulfate. It should be used with caution in patients with a history of allergic reactions.

Directions

Administer the solution as directed by a healthcare professional. It should be visually inspected for particulate matter and discoloration before administration.

Scientific Evidence

Studies have shown that Protamin solution effectively reverses the anticoagulant effects of heparin. Research published in the Journal of Thrombosis and Haemostasis demonstrated the rapid and reliable neutralization of heparin by protamine sulfate.

Additional Information

Protamin solution should be stored at controlled room temperature. It is essential to follow proper disposal procedures for any unused portions.

Pharmacological Effects: Protamin acts by binding to heparin molecules, forming a stable complex that neutralizes the anticoagulant activity of heparin. This interaction prevents further anticoagulant effects, allowing for normal clotting mechanisms to resume.

Clinical Trials: Clinical trials have demonstrated the efficacy and safety of Protamin solution in reversing heparin anticoagulation. A randomized controlled trial published in the New England Journal of Medicine showed that Protamin effectively reversed heparin’s anticoagulant effects within minutes of administration, with no serious adverse events reported.