Description

Protamin Sulfate solution for injections 1000 ME/ml. 10 ml. vial №1

Ingredients

Each ml contains Protamin Sulfate 1000 ME (Mega-Units).

Dosage

The dosage should be determined by a healthcare professional based on individual patient needs. It is typically administered by injection into a vein or muscle.

Indications

Protamin Sulfate is indicated for the treatment of heparin overdose or to reverse the anticoagulant effects of heparin. It works by binding to heparin, neutralizing its anticoagulant activity.

Contraindications

Do not use Protamin Sulfate if there is a known hypersensitivity to the drug. It should be used with caution in patients with a history of allergies.

Directions

Administer as directed by a healthcare provider. Monitor for any signs of allergic reactions or adverse effects during administration.

Scientific Evidence

Protamin Sulfate has been extensively studied for its efficacy in reversing the anticoagulant effects of heparin. Research published in the Journal of Thrombosis and Haemostasis demonstrated the rapid and reliable reversal of heparin activity with Protamin Sulfate, making it a crucial antidote in clinical practice.

Additional Information

Protamin Sulfate acts by forming a stable complex with heparin, preventing it from further inhibiting clotting factors. This mechanism of action allows for the rapid restoration of normal coagulation parameters in patients at risk of bleeding due to heparin therapy.

Clinical trials have shown that Protamin Sulfate is highly effective in managing heparin-related complications, with minimal side effects when used appropriately. Its role as a specific antidote for heparin makes it an essential medication in various medical settings.