Description

Protamin Sulfate Solution for Injections 1000ME/ml. 10 ml. Vial №1

Ingredients:

Each milliliter contains 1000 milligrams of Protamin Sulfate.

Dosage:

The dosage should be determined by a healthcare professional based on the patient’s condition. It is typically administered by injection into a vein or muscle.

Indications:

Protamin Sulfate is used as an antidote to heparin. It works by binding to heparin, neutralizing its anticoagulant effects.

Contraindications:

Do not use Protamin Sulfate if you are allergic to it or have a history of severe allergic reactions to fish products.

Directions:

Administer as directed by a healthcare provider. It is important to follow proper injection techniques to avoid complications.

Scientific Evidence:

Studies have shown that Protamin Sulfate effectively reverses the anticoagulant effects of heparin. Research published in the Journal of Thrombosis and Haemostasis demonstrated the efficacy of Protamin Sulfate in managing heparin overdose cases.

Additional Information:

Protamin Sulfate should be used with caution in patients with a history of fish allergies due to its source from fish sperm. It is essential to monitor for signs of allergic reactions during administration.

Protamin Sulfate’s pharmacological action involves forming a stable complex with heparin molecules, preventing them from inhibiting clotting factors. This interaction effectively reverses the anticoagulant effects of heparin, making it a crucial antidote in cases of heparin overdose or during surgery where rapid reversal of heparin’s effects is necessary.