Description

Ranexa 500 (ranolazine) tablets with prolonged release 500 mg. №60

Ingredients

Active ingredient: Ranolazine 500 mg.
Other ingredients: Microcrystalline cellulose, hypromellose, magnesium stearate, and more.

Dosage

Recommended dosage: The usual dose is 500 mg twice daily. The tablets should be swallowed whole and not crushed or chewed.

Indications

Ranexa 500 tablets are indicated for the treatment of chronic angina. It helps to reduce the frequency of episodes of chest pain and can improve exercise tolerance.

Contraindications

Do not use Ranexa 500 tablets if you have liver cirrhosis or if you are taking strong CYP3A inhibitors. It is important to consult a healthcare provider before starting this medication.

Directions

Take Ranexa 500 tablets exactly as prescribed by your doctor. Do not alter the dosage unless instructed to do so. It is important to follow a healthy lifestyle along with the medication for best results.

Scientific Evidence

Ranolazine, the active ingredient in Ranexa 500 tablets, works by inhibiting the late sodium current in cardiac cells, which helps to reduce intracellular calcium overload during ischemia. Studies have shown that ranolazine can improve exercise tolerance and reduce angina symptoms in patients with chronic angina pectoris (Belardinelli L, et al., 2006).

Additional Information

It is important to inform your healthcare provider about all the medications you are currently taking before starting Ranexa 500 tablets. This medication may interact with certain drugs, so caution is advised. If you experience any unusual symptoms while taking Ranexa, seek medical attention immediately.

Pharmacological Effects: Ranolazine acts by inhibiting the late sodium current in cardiac cells, leading to a reduction in intracellular calcium overload during ischemia. This mechanism helps in improving myocardial relaxation and oxygen utilization, ultimately reducing angina symptoms.

Clinical Trials: Clinical trials have demonstrated the efficacy of Ranexa 500 tablets in reducing angina episodes and improving exercise capacity in patients with chronic angina. The drug has shown comparable effectiveness to traditional antianginal medications while offering a favorable side effect profile.