Description

Ravel SR (Indapamid) Tablets of Prolonged Action 1.5 mg. №30

Ingredients

Active ingredient: Indapamide 1.5 mg.
Other ingredients: lactose monohydrate, maize starch, colloidal anhydrous silica, magnesium stearate.

Dosage

Recommended dosage: The usual dose is one tablet daily, preferably in the morning. The tablet should be swallowed whole with a sufficient amount of water.

Indications

Indicated for: Hypertension (high blood pressure) and edema (fluid retention) associated with congestive heart failure.

Contraindications

Do not use if: allergic to indapamide, have severe kidney or liver disease, or are unable to urinate.

Directions

Directions for use: Take the tablet as directed by your healthcare provider. Do not exceed the recommended dose.

Scientific Evidence

Indapamide, the active ingredient in Ravel SR tablets, is a thiazide-like diuretic that works by increasing the excretion of sodium and water by the kidneys. Studies have shown that indapamide is effective in lowering blood pressure and reducing edema. Research published in the Journal of Hypertension demonstrated that indapamide has a sustained antihypertensive effect and is well-tolerated by patients.

Additional Information

It is important to monitor electrolyte levels regularly while taking Ravel SR tablets, especially potassium levels. Contact your healthcare provider if you experience symptoms like muscle weakness, irregular heartbeat, or excessive thirst while on this medication.

Pharmacological Effects

Indapamide acts primarily by inhibiting sodium reabsorption in the distal convoluted tubules of the kidneys. This leads to increased excretion of sodium and water, resulting in decreased blood volume and reduced peripheral resistance, ultimately lowering blood pressure. Additionally, the vasodilatory effects of indapamide contribute to its antihypertensive action.

Clinical Trials and Comparative Effectiveness

Clinical trials have shown that Ravel SR tablets provide effective and sustained blood pressure control with once-daily dosing. In comparative studies, indapamide has been found to be as effective as other antihypertensive medications with a lower risk of adverse metabolic effects. A study published in the American Journal of Hypertension compared the efficacy of indapamide with hydrochlorothiazide and found indapamide to be superior in reducing blood pressure with fewer metabolic side effects.

• Indicated for hypertension and edema associated with heart failure
• Take one tablet daily in the morning
• Avoid if allergic to indapamide or have severe kidney/liver disease
• Monitor electrolyte levels regularly