Remavir (rimantadine) capsules 100 mg. №30

Description

Remavir (rimantadine) capsules 100 mg. №30

Composition

active substance: rimantadine;

1 capsule contains rimantadine hydrochloride 100 mg;

excipients: lactose, monohydrate; potato starch; stearic acid; titanium dioxide (E 171); dye “Yellow sunset FCF” (E 110); gelatin.

Medicinal form

Capsules.

Main physico-chemical properties: hard, white gelatin capsules containing powder of orange color with a shade from slightly pink to brownish, with white inclusions.

Pharmacotherapeutic group

Antiviral means for systemic use. Rimantadine
ATX code J05A C02.

Pharmacological properties

Rimantadine hydrochloride is a derivative of amantadine, has pronounced antiviral activity. It is effective against various influenza viruses of type A, and also exhibits an antitoxic effect in influenza caused by virus type B. Remavir inhibits the replication of the virus in the early stages of the cycle by disrupting the formation of the viral envelope. Genetic experiments have shown that the specific protein of the M2 gene of the virion is of great importance in the antiviral effect of rimantadine against the influenza A virus. In vitro, rimantadine inhibits the replication of all three antigenic subtypes (H1N1, H2N2, H3N3) of the influenza virus detected in humans. Remavir does not affect the immunogenic properties of the inactivated influenza A vaccine.

Indication

Early treatment of influenza A virus in adults and children over 10 years of age.
Prevention of influenza type A during the epidemic in adults and children over 10 years.

Contraindication:

• Hypersensitivity to rimantadine, adamantane derivatives or excipients.
• Severe hepatic and renal impairment.
• Acute and chronic liver and kidney diseases.
• Thyrotoxicosis.
• Pregnancy and breastfeeding.

Use during pregnancy or breastfeeding

Remavir capsules crosses the placental barrier, passes into breast milk, so the use of the drug during pregnancy and breastfeeding is contraindicated.

Method of application and dosage

Take internally, after meals, drinking water. The Remavir capsules cannot be chewed.
The use of Remavir should be started as early as possible, immediately after the first symptoms of the flu appear. The therapeutic effect is more pronounced if the drug is taken within the first 48 hours after the first symptoms of flu appear.

Treatment for influenza: adults and children over 10 years old – 100 mg 2 times a day.

Before using the drug for children, be sure to consult a doctor.

Elderly patients (over 65 years) – 100 mg once a day.

The duration of the treatment course is 5 days.

Flu prevention: adults and children over 10 years old – 100 mg 2 times a day.

Elderly patients or patients with a high risk of complications – 100 mg once a day.

The drug Remavir 100 mg should be started at the beginning of the flu epidemic and used during the epidemic, but not longer than 2 weeks.

For patients with liver and/or kidney function disorders of mild or moderate severity, if necessary, the dose is adjusted: 100 mg 1 time per day. Patients should be closely monitored.

Children

The drug Remavir 100 mg can be used in children over 10 years of age after consulting a doctor.

Overdose

In cases of overdose – symptomatic therapy to maintain vital functions of the body.
There is information about a case of poisoning by a chemical analogue – amantadine.

Symptoms: agitation, hallucinations, arrhythmia, fever, chills, sweating, arrhythmia, hypoaesthesia, increased tearing, dysphagia, constipation, increased urination, stomatitis, eye pain.

Treatment: drug withdrawal, gastric lavage, intravenous physostigmine: adults 1-2 mg, children – 0.5 mg, if repeated administration is required, but not more than 2 mg per hour. Rimantadine and amantadine are not removed by hemodialysis.

Side effects

The drug is usually well tolerated.

• From the gastrointestinal tract: dyspepsia (nausea, vomiting), uncommon: abdominal pain, diarrhea, indigestion, dry mouth, anorexia.
• From the nervous system: insomnia, impaired concentration, dizziness, headache, fatigue, tremor, hallucinations, convulsions, confusion, ataxia (impaired coordination), drowsiness, increased agitation, depression, euphoria, hyperkinesis (spontaneous movements), change / loss of taste , parosmia.
• From the heart: palpitations, heart failure, edema, impaired cardiac conduction (blockade), tachycardia.
• From the vessels: hypertension, cerebrovascular disorders, syncope.
• From the genitals and mammary glands: galactorrhea.
• From the vestibular apparatus and hearing organs: noise / ringing in the ears.
• From the respiratory system: cough, dyspnea (shortness of breath), bronchospasm.
• From the skin and subcutaneous tissue: rash, itching, urticaria.
• From the immune system, skin and subcutaneous tissue: pale skin, possible hypersensitivity reactions, including skin rash, itching, urticaria.
• General disorders: asthenia (weakness), exacerbation of concomitant chronic diseases.

Usually the side effects disappear after taking the drug.