Remavir (rimantadine) powder 20 mg/dose sachets 1 g. №15

Description

Remavir (rimantadine) powder 20 mg/dose sachets 1 g. №15

Composition

active substance: rimantadine;

1 bag contains rimantadine hydrochloride 20 mg;

excipients: ascorbic acid, mannitol (E 421), aspartame (E 951), raspberry flavor Durarom.

Medicinal form

The powder is dosed.

Main physico-chemical properties: powder from almost white or white with a pink tint to cream color with yellow inclusions.

Pharmacotherapeutic group

Antiviral means for systemic use. Rimantadine.
ATX code J05A C02.

Pharmacological properties

Rimantadine is a derivative of amantadine, has pronounced antiviral activity. It is effective against influenza viruses of type A2, and also exhibits an antitoxic effect in influenza caused by virus type B. Rimantadine inhibits the replication of the virus in the early stages of the cycle by disrupting the formation of the viral envelope. Genetic studies have shown that the specific protein of the M2 gene of the virion plays an important role in the antiviral effect of rimantadine against the influenza A virus. In vitro, rimantadine inhibits replication of all three antigenic subtypes of influenza A virus (H1N1, H2N2, H3N3) detected in humans. Rimantadine does not affect the immunogenic properties of the inactivated influenza A vaccine.

Indication

Treatment of influenza A in the early stages of the disease in children aged 1 year.
Be sure to consult a doctor before using the drug.

Contraindication

Hypersensitivity to rimantadine, to derivatives of the adamantane group or to excipients.
Acute liver disease, acute and chronic kidney disease, thyrotoxicosis.
The drug contains aspartame, a source of phenylalanine. Its use is contraindicated in patients with phenylketonuria.

Use during pregnancy or breastfeeding

Remavir powder passes through the placental barrier into breast milk, so it is contraindicated during pregnancy or breastfeeding.

Method of application and dosage

Be sure to consult a doctor before using the drug.
If you have flu symptoms (fever, muscle aches, headache, eye pain), Remavir powder should be started as early as possible. The therapeutic effect is more pronounced if the drug is started within the first 48 hours after the onset of the disease.
Dissolve the contents of the sachet in ½ glasses of warm water and take orally after meals.

Treatment:

• Children aged 1 to 10 years should be prescribed 5 mg / kg body weight per day in 2-3 doses, but not more than 100 mg of Remavir 20 mg (5 sachets) per day.
• Children from 11 to 14 years – 140-160 mg of the drug (7-8 sachets) per day in several doses.
• Doses for adults over 14 years of age (use Remavir, tablets in a dosage of 50 mg).

The duration of treatment is 5 days.

Children

Efficacy and safety of the drug in children under 1 year has not been established.
The drug Remavir powder in this dosage form should be used in children aged 1 to 14 years.

Overdose

Symptoms: increased tearing, increased urination, fever, chills, agitation, constipation, sweating, dysphagia, stomatitis, hypoesthesia, eye pain.

Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions, drug withdrawal, intravenous physiostigmine in children – 0.5 mg if repeated administration is required, but not more than 2 mg per 1 hour.

Rimantadine and amantadine are not removed by hemodialysis.

Side effects

The drug is usually well tolerated.

• From the gastrointestinal tract: dyspepsia (nausea, vomiting), uncommon: abdominal pain, diarrhea, indigestion, dry mouth, loss of appetite.
• From the nervous system: insomnia, impaired concentration, dizziness, headache, fatigue, tremor, hallucinations, convulsions, confusion, ataxia (impaired coordination), drowsiness, increased agitation, depression, euphoria, hyperkinesis (spontaneous movements), change / loss of taste, parosmia.
• From the heart: palpitations, heart failure, edema, impaired cardiac conduction (blockade), tachycardia.
• From the vessels: hypertension, cerebrovascular disorders, syncope.
• From the genitals and mammary glands: galactorrhea.
• From the vestibular apparatus and hearing organs: noise / ringing in the ears.
• From the respiratory system, chest and mediastinum: cough, dyspnea (shortness of breath), bronchospasm.
• From the skin and subcutaneous tissue: rash, itching, urticaria.
• On the part of the immune system: pale skin, possible hypersensitivity reactions, including skin rash, itching, itching, urticaria.
• General disorders: asthenia (weakness), exacerbation of concomitant chronic diseases, fatigue.

Usually the side effects disappear after taking the drug.

If any side effects occur, you should stop taking the drug and see a doctor.