Respix L (ambroxol hydrochloride, loratadine) coated tablets №10

$8.00

Manufacturer: India

Symptomatic therapy of diseases of the respiratory tract with an allergic component, associated with violation of bronchial secretion and weakening of the promotion of mucus.

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Description

Respix L (ambroxol hydrochloride, loratadine) coated tablets №10

Composition

active substances: ambroxol hydrochloride, loratadine;

1 tablet contains ambroxol hydrochloride 60 mg, loratadine 5 mg;

excipients: lactose monohydrate, corn starch, microcrystalline cellulose, povidone, magnesium stearate, colloidal anhydrous silicon dioxide, sodium starch glycolate.

Medicinal form

Tablets.

Main physicochemical properties: flat, round tablets, almost white in color, with a line on one side, without a shell.

Pharmacotherapeutic group

Means used for coughs and colds. Expectorants, with the exception of combined preparations containing antitussives.
ATX code R05С.

Pharmacological properties

Ambroxol
Ambroxol increases the secretion of the glands of the respiratory tract, enhances the release of pulmonary surfactant by direct action on type II pneumocytes in the alveoli and Clara cells in the bronchioles, and also stimulates ciliary activity, as a result of which mucus secretion and its removal (mucociliary clearance) are facilitated.

Activation of fluid secretion and increase in mucociliary clearance facilitate the removal of mucus and relieve cough.

Improvement of mucociliary clearance was proven during clinical and pharmacological studies.

In vitro studies have shown that ambroxol has a local anesthetic effect. This may be explained by the blocking properties of sodium channels (binding was reversible and concentration-dependent).

Also, in vitro studies demonstrated the anti-inflammatory effect of ambroxol, associated with a decrease in the release of cytokines from the blood and tissue binding of mononuclear and polymorphonuclear cells.

The use of ambroxol increases the concentration of antibiotics (amoxicillin, cefuroxime, erythromycin and doxycycline) in bronchopulmonary secretions and sputum.

Loratadine
Loratadine belongs to tricyclic selective blockers of peripheral H1-histamine receptors. When used in the recommended dose, it does not have a clinically significant sedative and anticholinergic effect. During long-term treatment, no clinically significant changes in indicators of vital functions, results of laboratory tests, data of physical examination of the patient or electrocardiogram were found. Loratadine has no significant effect on the activity of H2-histamine receptors. Does not block norepinephrine uptake and actually does not affect the cardiovascular system and pacemaker activity.

Indications

Respix L tablets is prescribed for chronic or acute diseases of the respiratory organs with an allergic component, accompanied by viscosity of sputum, difficulty in its discharge.

Contraindications

Respix L tablets should not be used:

  • with severe impairment of the kidneys / liver;
  • children under twelve years old;
  • with allergies, intolerance to the components of this medication.

Respix L tablets is used with caution in case of peptic ulcer or erosions of the stomach / intestines, in the II-III trimesters of pregnancy, while taking antitussive pharmaceuticals.

Application during pregnancy and lactation

The active molecules of this drug are able to penetrate the protective placental barrier. However, animal studies have not shown a negative impact on the development of the embryo (fetus), pregnancy / childbirth. However, precautions should be taken when taking the medication during pregnancy.
The drug is excreted in breast milk. Respix L tablets is not recommended for the treatment of mothers during breastfeeding, although its negative impact is not expected.

Method of administration and dosage

For adult patients, Respix L tablets is prescribed orally (by mouth) after meals.
Adult patients, as well as children over 12 years of age, are prescribed 1 tablet x 2 times / day.
There are no restrictions on the duration of the use of this pharmaceutical product. However, long-term therapy should only be carried out under medical supervision.
Respix L should not be used for more than 4-5 days without first consulting a doctor.

Overdose

Symptoms: Stool disorders (constipation or diarrhea), nausea, other dyspeptic symptoms.
Overdose treatment: it is required to immediately (in the first hours after taking the medicine) rinse the stomach or artificially induce vomiting, conduct symptomatic therapy.

Side effects:

  • Cardiac disorders: tachycardia, palpitations.
  • Neurological disorders: drowsiness, increased appetite, headache, insomnia, convulsions, dizziness, convulsions, dysgeusia.
  • Respiratory disorders: rhinorrhea.
  • Digestive disorders: dry mouth, diarrhea (loose stools), nausea, heartburn, constipation, gastralgia (pain in the supra-gastric region), salivation, gastritis, decreased sensitivity in the oral cavity, functional disorders of the liver.
  • Urinary disorders: dysuria.
  • Allergic reactions: contact dermatitis, angioedema Quincke (rapidly developing edema of the lips, face, larynx), urticaria, skin rashes, itching, anaphylactic type reactions (including shock).
  • Others: weakness, fever.