Rexetin (paroxetine) coated tablets 30 mg. №30

Description

Rexetin (paroxetine) coated tablets 30 mg. №30

Composition

active substance: paroxetine;
1 tablet contains 20 mg of paroxetine (in the form of 22.76 mg of paroxetine hydrochloride hemihydrate);

excipients:

composition of the tablet core: magnesium stearate, sodium starch glycolate (type A), hypromellose, calcium hydrogen phosphate dihydrate;

shell composition: polysorbate 80, macrogol 400, macrogol 6000, titanium dioxide (E 171), hypromellose.

Medicinal form

Film-coated tablets.

The main physical and chemical properties: white or almost white round biconvex tablets, with a diameter of approximately 9 mm, covered with a film shell, with a line on one side and an engraving on the other. The tablet can be divided into equal doses.

Pharmacotherapeutic group

Antidepressants. Selective serotonin reuptake inhibitors.
ATX code N06A B05.

Pharmacological properties

Paroxetine is a potent selective 5-hydroxytryptamine (5-HT, serotonin) reuptake inhibitor. Its antidepressant action and effectiveness in the treatment of obsessive-compulsive and panic disorders is due to the specific inhibition of 5-HT uptake by brain neurons. By its chemical structure, paroxetine differs from tricyclic, tetracyclic and other known antidepressants.

The drug has a low affinity for muscarinic cholinergic receptors. Unlike tricyclic antidepressants, it has little affinity for alpha1-, alpha2- and beta-adrenergic receptors, dopamine (D2), 5-HT1-like, 5-HT2- and histamine (H1-) receptors; does not affect psychomotor function and does not increase the depressant effect of ethanol.

Rexetin does not affect the activity of the cardiovascular system, does not cause clinically significant changes in blood pressure, heart rate and ECG parameters.

Rexetin, unlike antidepressants that inhibit the uptake of norepinephrine, has a much smaller effect on the hypotensive effect of guanethidine.

Indications

Rexetin is an antidepressant. Inhibits the reverse neuronal uptake of serotonin in the brain. Little effect on the seizure of norepinephrine, dopamine. It also has anxiolytic (anti-anxiety), psychostimulating properties.
Appointed:

• with obsessive-compulsive disorder (OKP);
• with generalized anxiety disorder;
• with depression of various causes, incl. states accompanied by anxiety;
• with panic disorder, incl. with agoraphobia (fear of being in a crowd);
• with social phobia;
• with post-traumatic stress disorder.

Contraindications

You can not appoint Rexetin:

• with allergies to the components of the drug;
• during treatment with monoamine oxidase inhibitors and within two weeks after;
• during pregnancy / lactation.
• under the age of 18.

Application during pregnancy and lactation

Contraindicated.

Method of administration and dosage

Rexetin should be taken once a day, without chewing, preferably in the morning with meals.
Depending on the clinical condition of the patient, the dosage of the drug can be changed after 2-3 weeks.
The recommended daily dose for depression is 20 mg. The healing effect usually develops gradually. The daily dose can be increased by 10 mg at intervals of one week, until a therapeutic effect is achieved. The maximum dose that can be taken per day is 50 mg.

Overdose

Signs of an overdose: tremor, nausea, vomiting, dilated pupils, general agitation, dry mouth, increased sweating, dizziness, drowsiness, redness of the facial skin.
When overdosing, it is necessary to ensure airway patency, oxygenation, gastric lavage, prescribe enterosorbents. Continuous monitoring of cardiac and other vital functions is recommended.

Side effects:

• Digestive disorders: decreased appetite, nausea, constipation / diarrhea, increased liver function tests, severe liver dysfunction.
• Neurological disorders: drowsiness, tremors, weakness, fatigue, paresthesia, irritability, insomnia, headache, dizziness, extrapyramidal disorders, somnambulism, epileptiform seizures, orofacial dystonia, increased intracranial pressure.
• Vegetative disorders: increased sweating, dry mouth.
• Perceptual disorders: visual impairment, mydriasis, an attack of acute glaucoma.
• Cardiovascular disorders: tachycardia, ECG changes, instability of blood pressure, fainting.
• Urinary and sexual disorders: violation of ejaculation, difficulty urinating, changes in libido.
• Dermatological reactions: redness of the skin, edema of the face and extremities, subcutaneous hemorrhages, anaphylactic reactions (bronchospasm, hives, angioedema), pruritus.
• Electrolyte imbalance: hyponatremia, edema, impaired consciousness, epileptiform symptoms.
• Others: myopathies, myalgia, hyperglycemia, hyperprolactinemia, fever, galactorrhea, hypoglycemia, development of a flu-like state, thrombocytopenia, increase / decrease in body weight, bleeding.
• Abrupt withdrawal of the drug can cause sensory disturbances, dizziness, fear, agitation, sleep disturbances, tremors, increased sweating, confusion, nausea, therefore, the termination of therapy should be done gradually (dose reduction every second day).