Rinza (paracetamol, chlorpheniramine maleate, caffeine) tablets №10

Description

Rinza (paracetamol, chlorpheniramine maleate, caffeine) tablets №10

Composition

active substances: paracetamol, chlorpheniramine maleate, caffeine, phenylephrine hydrochloride;

1 tablet contains: paracetamol – 500 mg, chlorpheniramine maleate – 2 mg, caffeine – 30 mg, phenylephrine hydrochloride – 10 mg;

auxiliary substances: colloidal anhydrous silicon dioxide, corn starch, sodium starch glycolate (type A), magnesium stearate, talc, povidone (K 30), dye Ponceau 4R (E 124).

Medicinal form

Tablets.

The main physical and chemical properties: round, flat tablets without a shell with beveled edges and a dividing line on one side, pink in color with dark pink and white inclusions.

Pharmacotherapeutic group

Analgesics. Other analgesics and antipyretics. Paracetamol, combinations without psycholeptics.
ATX code N02B E51.

Pharmacological properties

A combined drug with an analgesic, antipyretic and anti-inflammatory effect, which is due to the components included in the composition of the medicinal product.

Paracetamol has an analgesic and antipyretic effect. It reduces pain associated with runny nose, sore throat, headache, muscle and joint pain, and reduces high fever. The analgesic effect is due to the inhibitory effect on the synthesis of prostaglandins. The antipyretic effect is mediated by the effect on the hypothalamic center of thermoregulation.

Chlorpheniramine maleate is a blocker of H1-histamine receptors. Chlorpheniramine has an anti-allergic effect: reduces itching of the eyes, nose and throat, swelling and hyperemia of the mucous membranes of the nasal cavity, nasopharynx and paranasal sinuses, reduces exudative processes. Caffeine has a stimulating effect on the central nervous system, which reduces fatigue and drowsiness, and increases mental and physical performance. Phenylephrine hydrochloride stimulates alpha-adrenergic receptors of vascular smooth muscles. Thus, it causes a vasoconstrictor effect, which leads to a decrease in edema and hyperemia of the mucous membrane of the upper respiratory tract and nasal sinuses.

Indications

Rinza is used to relieve the symptoms of fever in acute respiratory diseases, to relieve pain syndrome of various etiologies (attacks of toothache, neuralgia, myalgia, arthralgia, pain in trauma, migraine and burns). Also, the drug relieves the condition of patients and relieves nasal congestion in acute respiratory viral infections and allergic reactions – rhinitis, rhinopharyngitis, sinusitis. Also, the drug can be used as part of complex therapy in the treatment of inflammatory lesions of the paranasal sinuses.

Contraindications

Rinza is not used to treat patients suffering from hypersensitivity to any of the drug’s components, organic damage to the cardiovascular system, as well as myocardial infarction, glaucoma, insomnia, increased nervous excitability, convulsive seizures and epilepsy, severe forms of diabetes mellitus, thyroid diseases, and kidney dysfunction and liver, prostatic hypertrophy, children under 15, pregnant and lactating.

Application during pregnancy and lactation

Rinza is not used to treat nursing or pregnant women. If necessary, drug treatment becomes a question of stopping lactation.

Method of administration and dosage

When using the tablet form, Rinza is taken one tablet from 3 to 4 times a day, while the maximum single dose should not exceed 2 tablets at a time. Duration of treatment is 5 days.

Overdose

Most often, Rinza’s treatment is well tolerated by patients, however, with excessive use of the drug, it is possible to develop digestive disorders, accompanied by nausea, vomiting, diarrhea, increased sweating, and some patients may experience rapid heartbeat and increased blood pressure. In severe forms of overdose, severe liver failure may occur. If a patient develops symptoms of an overdose, it is recommended to perform a gastric lavage and provide him with enterosorbents. As a specific therapy, the patient is administered SH-group donors; it is also possible to introduce precursors of the synthesis of glutathione-methionine and N-acetylcysteine.

Side effects

When Rinza is taken, some patients with individual hypersensitivity to the drug may experience nausea, pain in the stomach, diarrhea, increased heart rate and increased sweating.