$34.00
Manufacturer: Romania
In the complex therapy of the following diseases: diseases of the heart and vascular system: stable angina pectoris, chronic heart failure (NYHA I-III functional class), cardiomyopathy, functional disorders of the heart and vascular system; acute and chronic ischemic disorders of cerebral circulation; reduced working capacity, physical and psycho-emotional overstrain;
during the recovery period after cerebrovascular disorders, head injuries and encephalitis.
Description
Ripronat (meldonium) hard capsules 250 mg. №40
Composition
active substance: meldonium;
1 hard capsule contains meldonium 250 mg or 500 mg;
excipients: corn starch, colloidal anhydrous silicon dioxide, calcium stearate;
- 250 mg capsule (body and lid): titanium dioxide (E 171), iron oxide yellow (E 172), gelatin;
- 500 mg capsule (body and cap): titanium dioxide (E 171), iron oxide yellow (E 172), quinoline yellow (E 104), azorubin (E 122), Ponceau 4R (E 124), gelatin.
Medicinal form
Capsules are hard.
The main physical and chemical properties:
- capsules of 250 mg: hard shiny capsules of beige color, containing homogeneous powder of white or almost white color;
- capsules of 500 mg: hard shiny capsules with a red cap and a beige body, containing a homogeneous white or almost white powder.
Pharmacotherapeutic group
Other cardiac drugs.
ATX code C01E B22.
Pharmacological properties
It is a remedy that improves metabolic processes in the heart muscle. In conditions of ischemia (insufficient blood supply), it restores the cellular balance between oxygen consumption and its delivery, prevents disruption of ATP transport, activates glycolysis without additional oxygen consumption. It helps to increase performance, reduce the severity of signs of physical and mental overstrain, activate immunity. Has a cardioprotective effect. In case of acute ischemic myocardial injury, it reduces the zone of necrosis and shortens the rehabilitation period.
Indications
Ripronat capsules is used:
- with diseases of the heart, vascular system (chronic insufficiency, stable exertional angina, cardiomyopathy, functional disorders);
- with acute / chronic disorders of cerebral circulation;
- with reduced performance, psychoemotional or physical overstrain;
- during the recovery period after head injuries, cerebrovascular disorders, encephalitis.
Contraindications
Ripronat capsules is contraindicated:
- with intolerance to the components of the drug;
- with increased intraocular pressure;
- with severe dysfunction of the liver, kidneys.
Application during pregnancy and lactation
Contraindicated.
Method of administration and dosage
Ripronat capsules is administered orally, preferably in the morning.
The standard dose for adults with diseases of the heart, vascular system – 500-1000 mg / day, maximum – 1000 mg / day.
Standard doses for acute / chronic disorders of cerebral circulation – 500 mg / day, maximum – 500 mg / day.
The duration of therapy is 4-6 weeks with a frequency of 2-3 times a year.
Overdose
The drug Ripronat capsules is low toxic.
Possible symptoms: decreased blood pressure, tachycardia, dizziness, weakness.
Treatment is symptomatic. Monitoring of kidney and liver function is required.
Side effects:
- Urinary disorders: pollakiuria.
- Immune disorders: allergic dermatitis, urticaria, angioedema, anaphylactic reactions.
- Mental disorders: sleep disturbances, fear, agitation, obsessive thoughts.
- Neurological disorders: paresthesia, cephalalgia, tremor, vertigo, hypesthesia, tinnitus, gait disturbance, loss of consciousness.
- Cardiovascular disorders: palpitations, cardiac arrhythmias, tachycardia, discomfort in the region of the heart, atrial fibrillation, instability of blood pressure, hyperemia, skin pallor, hypertensive crisis.
- Respiratory disorders: pharyngitis, cough, apnea, dyspnea.
- Gastrointestinal disorders: dyspepsia, loss of appetite, dysgeusia (metallic taste in the mouth), nausea, diarrhea, flatulence, hypersalivation, dry mouth.
- Dermatological disorders: macular, papular eruptions, itching.
- Musculoskeletal disorders: back pain, myasthenia gravis, muscle spasms.
- General: weakness, asthenia, chills, swelling of the legs, face, cold sweat, hot or cold sensation.
- Laboratory changes: increased levels of C-reactive protein, dyslipidemia, abnormalities in the electrocardiogram, eosinophilia, tachycardia.
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