Description

Rotaritmil (Amiodarone) Tablets 200 mg. №30

Ingredients

Active ingredient: Amiodarone hydrochloride 200 mg per tablet.

Dosage

Recommended dosage: The usual maintenance dose is 200-400 mg daily. Dosage should be individualized based on the patient’s condition and response.

Indications

Indicated for: Treatment of various types of serious irregular heartbeats (arrhythmias) such as ventricular fibrillation, ventricular tachycardia, and atrial fibrillation.

Contraindications

Do not use if: Hypersensitive to amiodarone or any component of the formulation, severe sinus-node dysfunction, or second- or third-degree AV block.

Directions

Administration: Take as directed by a healthcare provider. Swallow the tablet whole with water, do not crush or chew. Can be taken with or without food.

Scientific Evidence

Amiodarone has been extensively studied for its efficacy in managing various arrhythmias. Research published in the *New England Journal of Medicine* has shown that amiodarone is effective in reducing the recurrence of atrial fibrillation compared to placebo and other antiarrhythmic drugs.

Additional Information

It is important to regularly monitor thyroid function, liver enzymes, and lung function while on amiodarone therapy. This medication may interact with other drugs, so inform your healthcare provider about all medications you are taking.

Pharmacological Effects: Amiodarone works by prolonging the action potential and refractory period of the heart muscle, thereby stabilizing the heart rhythm. It also has non-competitive alpha- and beta-adrenergic blocking effects, contributing to its antiarrhythmic properties.

Clinical Trials: Clinical trials have demonstrated the superior efficacy of amiodarone in maintaining sinus rhythm in patients with atrial fibrillation compared to other antiarrhythmic agents. Additionally, its long half-life allows for once-daily dosing, improving patient compliance.