Secnidox (secnidazole) coated tablets 1g. №2

Description

Secnidox (secnidazole) coated tablets 1g. №2

Composition

active ingredient: secnidazole;

1 film-coated tablet contains secnidazole 1.0 g;

excipients: corn starch, calcium hydrogen phosphate, microcrystalline cellulose, sodium starch glycolate (type A), povidone (K 30), magnesium stearate, talc;

shell composition: hypromellose (E 15), titanium dioxide (E 171), indigo carmine varnish (E 132), talc, propylene glycol.

Dosage form

Film-coated tablets.

Basic physical and chemical properties: capsule-shaped tablets, film-coated, blue in color with “SECN” embossed on one side and a notch on the other.

Pharmacological group

Antiprotozoal agents. Nitroimidazole derivatives.
ATX code R01A B07.

Pharmacological properties

Secnidox is an antiprotozoal drug of the nitroimidazole group with antibacterial action. Secnidox is characterized by bactericidal (against gram-positive and gram-negative anaerobic bacteria) and amebicidal (intra- and external-intestinal) effect. Secnidox is particularly active against Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia. Penetrating into the cell of the microorganism, secnidazole is activated by the reduction of the 5-nitro group, thereby interacting with cellular DNA. There is a violation of its helical structure and the destruction of strands, inhibition of nucleotide synthesis and cell death.

Indication:

• Trichomonas urethritis and vaginitis (caused by Trichomonas vaginalis);
• bacterial vaginosis;
• intestinal amoebiasis (caused by Entamoeba histolytica);
• liver amoebiasis (caused by Entamoeba histolytica);
• giardiasis (caused by Giardia lamblia).

Contraindication:

• Hypersensitivity to secnidazole and other imidazole derivatives;
• organic diseases of the central nervous system (CNS).

Method of application and dosage

The drug is intended for oral use. Tablets should be swallowed whole immediately before eating with a small amount of water.

Dosage for adults

Trichomonas urethritis and vaginitis, bacterial vaginosis: the drug is used at a dose of 2 g (2 tablets) once.

Intestinal amebiasis:

• Acute amoebiasis: the drug is used at a dose of 2 g (2 tablets) once;
• Asymptomatic amebiasis, including focal and cystic forms: the drug is used at a dose of 2 g (2 tablets) 1 time per day for 3 days.
• Amebiasis of the liver: the drug is used at a dose of 1.5 g (1.5 tablets) 1-2 times a day for 5 days.
• Giardiasis: the drug is used at a dose of 2 g (2 tablets) 1 time per day for 3 days.

Dosage for children

Intestinal amebiasis:

• Acute amoebiasis: the drug is used at a dose of 30 mg/kg of body weight once;
• Asymptomatic amoebiasis, including focal and cystic forms: the drug is used at a dose of 30 mg/kg of body weight 1-2 times a day for 3 days.
• Amebiasis of the liver: the drug is used at a dose of 30 mg/kg of body weight 1-2 times a day for 5 days.
• Giardiasis: the drug is used at a dose of 30 mg/kg of body weight (1–1.5 g) once.

Children

The drug should be used in children over 12 years of age.

Overdose

Symptoms: possible increase in side effects.
Treatment: there is no specific antidote. If necessary, carry out symptomatic therapy.

Side effects

Secnidox is easily tolerated, but side effects may occur:

• general disorders: general weakness;
• from the digestive tract: indigestion, nausea, pain in the stomach, metallic taste in the mouth, glossitis, stomatitis.

Less common:

• from the hematopoietic system: moderate reversible leukopenia, reversible neutropenia.
• Allergic reactions: hypersensitivity reactions, including redness, rash, urticaria.