Sentor (losartan) coated tablets 100 mg. №30

Description

Sentor (losartan) coated tablets 100 mg. №30

Composition

active substance: losartan;

1 film-coated tablet contains 50 mg or 100 mg of losartan potassium;

excipients:

core: microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, colloidal anhydrous silicon dioxide, magnesium stearate;

shell: Opadry II white (hypromellose, titanium dioxide (E 171), lactose monohydrate, macrogol, glycerol triacetate).

Medicinal form

Film-coated tablets.

The main physical and chemical properties:

• Tablets of 50 mg: round, biconvex, film-coated tablets, white or almost white in color, with a line on one side and “50” on the other.
• Tablets of 100 mg: oval, biconvex tablets, covered with a shell, white or almost white in color, engraved “100” on one side, the other side is smooth.

Pharmacotherapeutic group

Simple preparations of angiotensin II receptor antagonists.
ATX code C09C A01.

Pharmacological properties

This drug belongs to the group of drugs – type II angiotensin receptor antagonists, based on losartan potassium.
The main active ingredient, potassium losartan, is a vasoconstrictor, an active hormone related to the renin-angiotensive system. Angiotensin II is able to bind to the AT1 receptor found in various tissues of the body. Particularly in the smooth muscle of the blood vessels, which are part of the adrenal glands, kidneys and heart muscle.
Promotes the proliferation of smooth muscle cells.
This hormone also has the property of detecting various biological reactions, including the reaction of vasoconstriction and the release of the hormone aldosterone, which is the main mineralocorticosteroid hormone of the adrenal cortex.
Losartan is able to selectively bind to the AT1 receptor, while not binding or blocking other hormone and ion channel receptors. Also, this hormone does not have the ability to inhibit the ACE enzyme that promotes the breakdown of bradykinin.

Indications

This drug is used to treat arterial hypertension – a condition in which a person has a persistent increase in blood pressure, from 140/90 mm Hg and above.

Also used for:

• arterial hypertension, accompanied by left ventricular hypertrophy, in order to reduce the risk of complications and mortality due to cardiovascular disorders;
• type II diabetes mellitus with proteinuria, to slow the progression of kidney disease, as well as to reduce proteinuria;
• chronic heart failure.

Contraindications Sentor 

Not applicable if the patient has hypersensitivity (allergy) to one of the components that make up the drug.
Contraindicated in severe hepatic failure.
It is not used in pediatrics until the age of 6.

Application during pregnancy and lactation

It is not used to treat pregnant women.
If there is a need to take this drug, then during treatment, lactation (breastfeeding) should be suspended.

Method of administration and dosage

The drug Sentor is taken orally, by mouth, regardless of the meal, once a day.
The recommended average daily dose is 50 mg.
The maximum hypotensive effect develops no earlier than 3-6 weeks after starting treatment with this drug.
If necessary, it is allowed to increase the daily dosage to 100 mg, which is also the maximum permissible daily dose.
When prescribing to patients receiving high doses of diuretics, the initial dose should be reduced to 25 mg per day.
Other dosages:

• heart failure – 12.5 mg, with a weekly increase in dosage by 12.5 mg, until a maximum dosage of 150 mg per day is reached, maintenance dosage is 50 mg;
• children weighing from 20 to 50 kg – 25 mg;
• adults weighing less than 50 kg – no more than 50 mg.

Patients with impaired liver function take a reduced dosage of the drug.
Elderly patients, patients with impaired renal function (including those on dialysis), as well as patients with mild to moderate hepatic impairment do not need dosage adjustment.
This drug can also be prescribed concurrently with the intake of other antihypertensive drugs.

Overdose

An overdose of the drug can cause:

• arterial hypotension;
• tachycardia;
• bradycardia (due to the activation of the parasympathetic nervous system).

In this case, treatment of symptoms, gastric lavage, and intake of enterosorbents is recommended.
The use of hemodialysis is recommended.

Side effects

Therapy with this drug can cause side reactions in the form of:

• dizziness, vertigo, drowsiness, headache, insomnia;
• sensations of palpitations, angina pectoris, tachycardia;
• symptomatic hypotension (especially in patients with a deficiency of intravascular fluid volume, for example, in patients with severe heart failure or those receiving high doses of diuretics), dose-dependent orthostatic effect, rash;
• abdominal pain, persistent constipation;
• asthenia, fatigue, edema, chest pain;
• increased ALT levels, hyperkalemia;
• anemia, thrombocytopenia;
• loss of consciousness;
• diarrhea, pancreatitis, hepatitis, liver dysfunction;
• back pain, muscle cramps;
• urinary tract infections;
• flu-like symptoms;
• ringing in the ears;
• erectile dysfunction, impotence;
• changes in the functioning of the kidneys, including renal failure (reversible phenomena).

If you are allergic to the drug, you may experience:

• anaphylactic reactions, angioedema;
• vasculitis, including Shenlein-Henoch purpura;
• migraine, cough;
• allergic urticaria, pruritus, rash, photosensitivity;
• myalgia, arthralgia;
• depression;
• hyponatremia.