Sermion (nicergoline) lyophilisate for solution for injection 4 mg. 4 ml. vials №4 with solvent

Description

Sermion (nicergoline) lyophilisate for solution for injection 4 mg. 4 ml. vials №4 with solvent

Composition

active substance: nicergoline;

1 vial contains 4 mg of nicergoline;

excipients: lactose, monohydrate; tartaric acid;

solvent: sodium chloride, benzalkonium chloride, water for injections.

Medicinal form

Lyophilisate for solution for injection.

Main physical and chemical properties: porous white lyophilisate.

Pharmacotherapeutic group

Means affecting the cardiovascular system. Peripheral vasodilators. Horn alkaloids. Nicergoline.
ATX code C04A E02.

Pharmacological properties

Nicergoline is an ergoline derivative with alpha-1-adrenergic blocking activity when administered parenterally. After oral administration, nicergoline undergoes rapid and significant metabolism with the formation of a number of metabolites, due to which activity is also observed at various levels of the central nervous system.

When administered orally, Sermion exhibits numerous neuropharmacological effects: it not only increases the intake and consumption of glucose in the brain, enhances the biosynthesis of protein and nucleic acids, but also affects various neurotransmitter systems.

Indications

Sermion lyophilisate is used in the treatment of acute and chronic cerebral vascular and metabolic disorders caused by atherosclerosis, arterial hypertension, thrombosis or cerebral vascular embolism, including dementia of vascular etiology, acute transient cerebrovascular accidents and circulatory disorders.
The drug is used in the treatment of acute and chronic peripheral vascular and metabolic disorders: Raynaud’s disease, functional and organic arteriopathies of the extremities, conditions caused by impaired peripheral blood flow.
In addition, Sermion lyophilisate is used in the complex treatment of hypertensive crises.

Contraindications

Acute bleeding, severe bradycardia, orthostatic hypotension, acute myocardial infarction, pregnancy and lactation period, intolerance to the components of the drug are considered absolute contraindications to the appointment of Sermion. In addition, Sermion tablets are not prescribed for patients with fructose intolerance, isomaltase or sucrase deficiency, glucose-galactose malabsorption, as well as for persons under 18 years of age.
A relative contraindication to the use of Sermion is gout, a history of hyperuricemia. So, care should be taken when prescribing a drug to patients who are taking drugs that cause metabolic disturbances and excretion of uric acid.

Application during pregnancy and lactation

The use of Sermion lyophilisate in the therapy of nursing and pregnant women is possible only in extreme cases, since the safety profile of nicergoline for this category of patients is unknown. The use of Sermion in the treatment of nursing and pregnant women is carried out only under strict medical supervision.

Method of administration and dosage

• Intramuscular injections: 2‒4 mg (2‒4 ml) twice a day (the solvent provided is used).
• Slow intravenous infusion: 4‒8 mg dissolved in 100 ml of saline or glucose solution. According to the doctor’s decision, this dose can be re-applied several times a day.

There is experience in the use of the drug Sermion by intra-arterial injection: 4 mg dissolved in 10 ml of physiological solution for 2 minutes.

The dosage regimen, duration of treatment and route of administration depend on the individual clinical situation. In some cases, it is advisable to start treatment with parenteral administration of the drug, and then switch to long-term oral administration.

The effect of treatment appears gradually. Since the therapy is usually long-term, the doctor needs to evaluate the feasibility of continuing treatment at certain intervals, but not less often than every 6 months.

Overdose

Even when Sermion is taken in doses significantly higher than therapeutic, patients do not have any negative symptoms, with the exception of a short-term decrease in arterial pressure.

Side effects

When taking Sermion, the development of side effects is very rarely observed. Sometimes, with prolonged use of the drug, patients may experience a decrease in blood pressure, cold extremities, dizziness, weakness, sweating, dyspeptic disorders, increased acidity of gastric secretions, sleep disturbances and allergic skin reactions.